To Analyze The Differences Of Risk Factors In Hypertensive Patients With Lacunar Infarction Among Han,Uygur,Kazak In Xinjiang

Objective: To investigate the differences of hypertensive patients with lacunar infarction of different ethnic groups(Han, Kazak and Uygur in Xinjiang). Methods: we investigated 12449 patients with hypertension during January.2003 to May. 2015 in our hospital. Of them 1678 patients had lacunar infarction. We investigated 1319 patients with Hypertension during January.2012 to May. 2015 in our hospital, Among patients 700 male,619 femal; 746 Hans, 343 Uygur, 230 Kazak. We Compared the three nationalities with general data, laboratory examination, differences in ABPP, carotid artery ultrasound and make relevant regression analysis. Results: In the 12449 hypertensive patients, 792 males had lacunar infarction and 886 femals had lacunar infarction. The females had a higher frequency of lacunar infarction than the males(x2=45.816,P < 0.001). There are 1253Hans(14.4%), 383 Uygur(11.4%) and 42 Kazak(10.5%) had hypertention with lacunar infarction. The Hans had a higher frequency of lacunar infarction than the Uygur and Kazak(x2=22.653,P < 0.001). The highest percent of hypertension patients occur acunar infarction age is 60~69 in Han, Uygur, and 50~59 in Kazak(x2=98.843,P <0.001). The1319 hypertensive patients with lacunar infarction are 256 Hans, 112 Uygur, 96 Kazak.The main parts of three nationalities hypertensive patients occurd lacunar infarction in turn are: bilateral basal ganglia region, centrum semiovale, corona radiata. But the lacunar infarction more likely occurd in frontal area of Han, in brainstem of Uygur, in corona radiate and brain parenchyma of Kazak(P<0.05). The carotid atheroselerosis all occurs in the common carotid artery of three nationalities. The carotid atheroselerosis occurs in the interal carotid artery percent from high to low in turn is Uygur, Kazakh and Han(P<0.05).The logistic regressions shows: Age, CyC, nSBP is closely related to the Hanshypertensive patients occurrence of lacunar infarction. Age, CyC, SBP in the morning,heart rates, carotid plaques is closely related to the Uygur hypertensive patients occurrence of lacunar infarction. Uygur hypertensive patients with carotid plaques are 2.613 times to have lacunar infarction than the people without lacunar infarction. Age, CyC is closely related to the Kazak hypertensive patients occurrence of lacunar infarction. Conclusion:This study shows in the hypertensive patients in Xinjiang, The genetic factors may be related to the percent of lacunar infarction and carotid atheroselerosis occurd in which area are different in the three nationalities. Age, CyC is closely related to hypertensive patients occurrence of lacunar infarction in the three nationalities. But Han is also associated with nSBP, Uygur is also associated with SBP in the morning, heart rates and carotid plaques.