The Correlation Between TLR2 Gene-597T/C Polymorphism And Primary ANCA Associated Small Vasculitis Of Han Population In Guangxi

Objective:To investigate the correlationship between Toll-like receptor2 (TLR2)gene promoter region-597T/C polymorphism and primary ANCA associated small vasculitis(AAV)in Guangxi Han nationality.Methods:A case control study was performed in our study.Patients with AAV (patients group,n=110) and healthy people(control group,n=200) were recruited.Clinical symptoms were observed, biochemical parameters in serum were detected and polymorphisms of TLR2 gene promoter 597T/C were analyzed by polymerase chain restricted fragment length polymorphisms (PCR-RFLP).Results:(1) The frequencies distribution of TLR2-597T/C genotype TT, TC and CC in 110 AAV patients were 54.55%,40.00% and 5.45%, respectively, and the frequencies of allele T and C were 74.55% and 25.45%, respectively. In control group, the genotype frequencies of TT,TC and CC were 56.00%,40.50% and 3.50%, respectively, with 76.25% of allele T and 23.75% of allele C.No significant differences were found in neither genotype distribution nor allele frequencies between the patients group and control group(P> 0.05). (2) Signifi- cant differences were found in the incidence of proteinuria rate and the hemoglobin (P< 0.05) in AAV patients. (3) There was no significant difference between AI and CI in TT, TC andCC genotype in AAV patients.Conclusions:It was indicated in our study that the polymorphism of TLR2-597T/C may be correlated with the incidence of the level of hemoglobin and proteinuria, while no obvious correlation with the susceptibility of ANCA associated in vasculitis Guangxi.