The Research Of The Correlation Between TCM Syndromes Of Hepatitis B Cirrhosis, Ultrasonic Elastography And Child-Pugh Grading Of Liver Function

Objects:This clinical research aims to investigate the correlation between TCM syndrome types of liver cirrhosis,ultrasonic elastography and the Child-Pugh grading of liver function. It also aims to search for the significance of ultrasound index in the diagnosis and differentiation of hepatitis B cirrhosis.If successes,it will give a new connotation to the TCM syndrome differentiation of hepatitis B cirrhosis.Methods:On the basis of reading the related literatures of liver cirrhosis, the researchers finished the design "Clinical symptoms of Hepatitis B liver cirrhosis record"and "TCM syndrome differentiation of Hepatitis B liver cirrhosis record"with the help of the professor. The researchers conducted a unified syndrome differentiation and finish the ultrasonic elastography the for the selected patients.They should also figure out their Child-Pugh classification of liver function. EXCEL and SPSS22.0 were used to process and analyze data.Results:This study included 103 cases of infectious diseases of Jiangsu Province Traditional Chinese Medicine Hospital which meet the criteria.There is no statistical significance in gender and age distribution between the different syndromes of patients(P>0,05); The difference between liver qi stagnation syndrome and other syndromes of the number of patients is statistically significant(P<0.05);There is no statistical significance in the difference of the maximum oblique diameter of the right lobe of the liver(P>0.05);The difference between damp-heat accumulation syndrome and other syndromes of the lengths of gallbladder is statistically significant(P<0.05). The difference between damp-heat accumulation syndrome and liver qi stagnation syndrome, spleen kidney yang deficiency syndrome of the anterior and posterior diameter of gallbladder is statistically significant(P<0.05). There is no statistical significance of dampness retention syndrome, liver kidney yin deficiency syndrome,blood stasis syndrome(P>0.05). There is no statistical significance in the difference of the lengths of gallbladder, the anterior and posterior diameter of gallbladder of other syndromes(P>0.05);The difference between blood stasis syndrome and other syndromes of the spleen intercostals thickness, spleen subcostal length is statistically significant(P<0.05). The difference between liver qi stagnation syndrome and dampness retention syndrome of the spleen intercostals thickness is statistically significant(P<0.05). There is no statistical significance in the difference of the spleen intercostals thickness, spleen subcostal length of other syndromes(P>0.05);The difference between spleen kidney yang deficiency syndrome,blood stasis syndrome and liver qi stagnation syndrome of the Inner diameter of portal vein is statistically significant(P<0.05).The difference between spleen kidney yang deficiency syndrome and blood stasis syndrome has no statistically significant.The difference between blood stasis syndrome and liver qi stagnation syndrome,dampness retention syndrome of the mean portal vein blood flow velocity is statistically significant(P<0.05). There is no statistical significance in the difference of the diameters spleen vein(P>0.05);The difference between liver qi stagnation syndrome,dampness retention syndrome,damp-heat accumulation syndrome of the ElastPQ is statistically significant(P<0.05). The difference between liver kidney yin deficiency syndrome,spleen kidney yang deficiency syndrome,blood stasis syndrome and liver qi stagnation syndrome,dampness retention syndrome,damp-heat accumulation syndrome is statistically significant(P<0.05). There is no statistical significance of the difference of liver kidney yin deficiency syndrome,spleen kidney yang deficiency syndrome,blood stasis syndrome(P>0.05);The Child-Pugh classification of liver function of liver qi stagnation syndrome,dampness retention syndrome,damp-heat accumulation syndrome is A level while the classification of liver kidney yin deficiency syndrome,spleen kidney yang deficiency syndrome,blood stasis syndrome is B and C level.The difference of the classification is statistical significance(P<0.05).The ElastPQ of A,B,C level is 12.54±1.27,15.57±2.65,18.35±2.11kPa. The difference of the ElastPQ is statistical significance(P<0.05).Conclusions:Gallbladder diameter may be suitable as a reference index of hepatitis B cirrhosis of stagnation of damp-heat accumulation syndrome;Spleen intercostal thickness, spleen rib length may be suitable as a reference index for hepatitis B cirrhosis of the liver blood stasis syndrome;ElastPQ may be suitable for hepatitis B cirrhosis of the liver, liver qi stagnation, moisture resistance, endoretention of damp heat syndrome as a reference index; It may not be suitable as a reference index for hepatitis B cirrhosis of the liver and kidney yin deficiency, spleen kidney yang deficiency, blood stasis blocking collaterals dialectical;The maximum oblique diameter of right lobe, anterior and posterior diameter of the gallbladder, the diameter of portal vein, the mean blood flow velocity of portal vein and splenic vein diameter may not be suitable as a reference index for the syndrome differentiation of hepatitis B cirrhosis;Hepatitis B liver cirrhosis early syndromes are liver qi stagnation syndrome,dampness retention syndrome and damp-heat accumulation syndrome.Late syndromes are liver kidney yin deficiency syndrome,spleen kidney yang deficiency syndrome and blood stasis syndrome.There is a correlation between TCM syndrome types of hepatitis B and liver cirrhosis and Child-Pugh grading of liver function. With the development of liver cirrhosis, the distribution of TCM syndromes showed dynamic changes, ultrasound elastography also showed different characteristics. The variation characteristics and the theory of traditional Chinese medicine on cirrhosis "qi stagnation, water stop-damp heat, yin deficiency and yang deficiency, blood stasis pathogenesis evolution law basically tallies. TCM syndrome differentiation and treatment of hepatitis B liver cirrhosis in clinic can refer to the content of ultrasound imaging, so as to improve the accuracy of syndrome differentiation.