| BackgroundGinkgo biloba, is a kind of high medicinal value plant, also known as ginkgo leaf, ginkgo tree is magical medical tree, leaves and fruits have high medicinal value. Standardized Ginkgo biloba extract has been widely used in the medical field, for example, improve memory, treat high blood pressure, headaches, depression and anxiety and other issues, which may be related to the main component of Ginkgo glycosides and ginkgolide physical activity, but also on their dilation of blood vessels action have some relevance. But for the therapeutic effect of Ginkgo biloba extract there is also a certain degree of controversy, this paper discusses the effect of Ginkgo biloba extract treatment of dementia.MethodWe searched six databases, including three Chinese databases HowNet China (China National Knowledge Infrastructure, CNKI,) knowledge Wanfang Data Services Platform (Wan Fang, WF) and Chongqing VIP-Chinese Science and Technology Journal Full Database (VIP), China Biomedical literature database (China Biology Medicine disc, CBM-disc) two foreign language database search foreign language database:PubMed (http://www.ncbi.nlm.nih.gov/pubmed), The Cochrane Library (http://www.cochrane library.com). Retrieving Chinese keyword "Yn xing ti qu wu", "chi dai", "a er ci hai mo bing", "xue guan xing chi dai", "hun he xing chi dai", the English key words "ginko", "dementia", "Alzheimer’s disease ", " vascular dementia ", " AD ", " VD "," mix dementia ".ResultThe meta-analysis included a total of 13 randomized controlled trials and experiments are all belong to the double-blind method, including a total of 625 cases of patients, basic medication time is between 8-52 weeks. In the meta-analysis, a change in cognitive scores between standardization group mean difference (SMD), showed that there was significant difference (-0.60,95% confidence interval [CI]-1.20 Ginkgo biloba extract with placebo;-0.01 p-value=0.04), but the daily capacity assessment (activities in daily living, ADL), did not reflect the superiority (SMD=-0.40 activity statistically significant,95%CI-0.56,0.02, p value= 0.07), the global assessment (global rating), (-0.46; 95%confidence interval CI-0.84,-0.20; P=0.01), this study heterogeneity higher. For the subgroup of Alzheimer’s disease, activities of daily living and cognitive function capability of SMD result of ginkgo extract drug treatment group than in the placebo group, the activities of daily living capacity test results (SMD=-0.34,95%CI-0.65,-0.16, P-0.004). Expulsion rates and side effects did not differ between the Ginkgo biloba extract and placebo. No consistent results are available for assessment of quality of life and neuropsychiatric symptoms may be due to the heterogeneity of the study population caused.ConclusionThe analysis results on the continuing role of Ginkgo biloba extract in patients 22-26 weeks, daily 240mg, can significantly improve the patient’s memory, functionality, and overall daily capacity assessment ginkgo extract compared with placebo, no significant side effects, and its role is better than placebo. But for this analysis is still not completely discharged publication bias, as well as some of the more ancient literature among the problems. |
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