Influence Of Glucocorticoid On Metabolism Of Calcium And Phosphorus In Children With Nephrotic Syndrome

ObjectiveTo study the influence of glucocorticoid (GC) treatment on metabolism of calcium and phosphorus in children with primary nephrotic syndrome(PNS).MethodsTwenty children with primary nephrotic syndrome who have accepted to hospital within one year were assigned as study group. Then treated them with glucocorticoid, at the same time together with calcium carbonate and vitamin D3 preparaton, serum levels of 25-OH-cholecalciferol(25-(OH)D3), parathyroid hormone(PTH), calcitonin(CT), calcium(Ca), phosphorus(P) were measured before GC treatment, and after four weeks treatment. Twenty healthy children during the same period were assigned as control group.Results1. In children with primary nephrotic syndrome(PNS), before GC treatment, the serum levels of 25-OH-cholecalciferol(25-(OH)D3) and Calcium was lower than those in control group (P< 0.05), the serum levels of parathyroid hormone(PTH) and phosphorus(P) were higher than those in control group (P<0.05), the serum level of calcitonin(CT) was no difference compared with that in control group (P>0.05).2. In children with primary nephrotic syndrome(PNS), after four weeks treatment, the serum level of 25-OH-cholecalciferol(25-(OH)D3) was significantly lower than that before GC treatment (P<0.01), also significantly lower than that in control group (P<0.01); the serum level of parathyroid hormone(PTH) was higher than that before GC treatment (P< 0.05), also significantly higher than that in control group (P<0.05); the serum level of calcium(Ca) was no difference compared with that before GC treatment (P> 0.05),but lower than that in control group (P< 0.05); the serum level of phosphorus(P) was lower than that before GC treatment (P<0.05),and was no difference compared with that in control group (P>0.05); the serum level of calcitonin(CT) was no difference compared with that before GC treatment and in control group (P>0.05)3. Conclusions1. There has been already disorder on metabolism of calcium and phosphorus in children with primary nephrotic syndrome(PNS) itself.;2. Treatment children with primary nephrotic syndrome(PNS) with glucocorticoid lead a worse disorder on metabolism of calcium and phosphorus;3. Treatment children with primary nephrotic syndrome(PNS) with glucocorticoid, serum levels of 25-OH-cholecalciferol(25-(OH)D3), parathyroid hormone(PTH), calcitonin(CT), calcium(Ca), phosphorus(P) should be measured,and reasonable application of calcium carbonate and vitamin D3 preparaton is necessary.