Expression Of LRG1 In Cervical Squamous Cell Carcinoma And The Relationship With Microvessel Density

Objective:This study was to investigate the expression of LRG1(Leucine-rich alpha-2-glycoprotein 1) and CD105(Endoglin) in normal cervical tissues,cervical intraepithelial neoplasia (CIN) Ⅱ-Ⅲ and cervical carcinoma. Furthermore, to explore the function of LRG1 in cervical carcinoma pathogenesis and the relationship between LRG1 and Microvessel density.Methods:The expression levels of LRG1 and CD105 was detected by immunohistochemistry in 40 cervical carcinoma tissues,20 CIN Ⅱ-Ⅲ tissues and 20 normal cervical tissues.Results:1.The percentage of LRG1 positive expression in cervical carcinoma tissues> CIN Ⅱ-Ⅲ tissues and normal cervical tissues is 80%、65%、10% respectively. The difference was statistically significant(P<0.05).2.The expression of LRG 1 in cervical cancer is correlated to clinical stage and lymph node metastasis (P<0.05). But there is no correlation between LRG1 expression and age、the size of tumor、pathologic grades and depth of invasion(P> 0.05).3. With the deepening of cervical lesions, CD105-MVD (X±s) is increasing. It is 4.852.109、3.85±7.020、22.53±8.855 respectively in normal cervical tissues、 CIN Ⅱ-Ⅲ tissues and cervical carcinoma tissues. The difference is statistically significant(P<0.05).4.The expression of CD105-MVD in cervical carcinoma is related to clinical stage、lymph node metastasis and the size of tumor, the difference was statistically significant(P<0.05). But there is no correlation between CD105-MVD and age、 pathologic grades and depth of invasion(P> 0.05).5.Positive correlationship was found between the expression of LRG1 and CD105-MVD (r=0.944,P<0.05)Conclusions The expression of LRG1 and CD105-MVD was up-regulated,as well as the positive correlation, which suggested that the abnormal expression of LRG1 and CD105-MVD may involved in the occurrence and development of cervical squamous cell carcinoma.