The Effect Of Implantation Window’s Displ Acement On Receptivity Of Endometrium In GnRH-a HRT Cycle

Objective: Receptivity and the role of clinical pregnancy after frozen embr yo transfer study in GnRH-a hormone replacement cycle endometrial growth pr ocess through retrospective analysis of shift endometrium implantation for recur rent endometrial planting failure patients, a prospective randomized controlled tr ial measured repeatedly confirmed after planting planting window shift promote embryonic development and the improvement of endometrial receptivity in patie nts with failed transplants day serum titer LIF and PIBF concentration, and thu s more conducive to improve the clinical pregnancy rate was further confirmed Early stage research.Methods: 1. A retrospective analysis of patients in our center 227 frozen embryo transfer planting GnRH-a repeated cycle of hormone replacement therap y failed, according to whether the patient has moved after planting window is divided into two groups, a total of 149 cases of the conventional group, impro vement in the conventional group were based on the planting window after pus hing the endometrium, a total of 78 patients evaluated by the conventional gro up and pregnancy and sex hormone levels and other factors related to improve ment of patients, explore the effect of endometrial implantation window after p ushing on pregnancy outcome.2. Comparison of the use of randomized controlled 88 cases of h ormone replacement frozen embryo transfer cycle data repeated implantation fai lure patients, the use of LIF and kit PIBF ELISA kits by staining(Elisa) for 88 cases collected repeatedly planting failed transplant patients daily serum sam ples were determined to give each patient the day of transplantation of thawed LIF concentration and PIBF concentration and pregnancy outcomes. After the 88 patients according to whether there is a packet of endometrial implantation window shift, conventional group, 47 cases of patients improved 41 cases. Rela tions between the two groups of serum LIF and serum PIBF concentration andthe pregnancy rate between the experimental study confirmed the conclusions of clinical research.Result: 1. Statistical analysis showed that patients improved clinical pregn ancy rate was significantly higher than the conventional group patients, and ser um progesterone levels day of embryo transfer has also improved significantly, endometrial growth significantly, statistical analysis found that both groups of p atients after injection of HCG serum progesterone and estrogen levels three day s also did not differ significantly, there was no difference transplant day estrog en levels.2. Determination of the conventional group and improvement of ser um LIF levels found in serum LIF levels of improvement was significantly hig her than the conventional group. By conventional group and the comparison gr oup improved pregnancy rates can also be found, improved group pregnancy ra te was significantly higher than the conventional group, results were consistent with the clinical retrospective study.3. By comparing the two groups of serum PIBF concentration, also found that serum concentrations of PIBF improvement was significantly higher than the conventional group, the difference was statistically significant.Conclusions : Repeated planting failure patients using GnRH-a hormone re placement thawed embryo transfer cycle, after planting window shift can contri bute to elevated serum progesterone levels, and promote their serum PIBF expr ession of LIF, improve the patient’s endometrial receptivity and improve The cl inical pregnancy rate. It provides a good basis for finding the right planting wi ndow clinically beneficial to make individualized treatment programs.