Relations Between Serum Salusin-α, Lipoprotein-associated Phospholipase A2 And Unstable Carotid Atheromatous Plaque Patients With Cerebral Infarction

Object:Cerebral artery atherosclerosis is the main reason leading to cerebral infarction,The mechanism are very complicated, the role of dyslipidemia and inflammatory reaction in AS get consensus, this project aimed at detection of salusin-α and Lipoprotein associated phospholipase A2 in cerebral infarction group,plaque group,and health subjects,To study the relationship between serum salusin-α,Lipoprotein associated phospholipase A2 and unstable carotid atheromatous plaque with cerebral infarction.Methods:One hundred patients with carotid unstable plaque confirmed by carotid ultrasound, divided into two groups as follows:cerebral infarction group(CI group,n=50) or not having cerebral infarction(plaque group,n=50)And 50 health subjects over the same period as control. Collect the general information : age, sex,index of body mass index(BIM),blood pressure,smoking history,examined the levels of total cholesterol(TC),Triglycerides(TG),high density lipoprotein(HDL),lowdensity Lipoprotein(LDL),glycosylated hemoglobin(Hb Alc), Homocysteine(HCY), C-reactive protein(CPR) after an overnight fast.The levels of serum salusin-α,Lp-PLA2 were detected by ELISA.Adopt SPSS17.0 software for statistical analysis. Measurement data are expressed as mean ± standard deviation,comparison between groups use one-way ANOVA,Equal Varance not assumed use rank sum test,attribute data expressed as a ratio with the chi-square test,correlation analysis:All the indexes of a test as relevant variables, cerebral infarction events occurred as dependent variables analyze the risk factors with logistic analysis.Results:(1)The general information:sex,age,smoking history,BIM,blood pressure,HDL showed no statistical significance, P>0.05,TC,TG,LDL,Hb Al,HCY,CPR were significantly hinger in CI group than in control group(P<0.05); TC、TG、LDL-C、Hb A1、HCY were significantly hinger in CI group than in plaque group(P<0.05);TG,CPR were significantly hinger in plaque group than in control group(P<0.05) between CI group,plaque group and control group;(2)Serum salusin-α level was significantly lower in CI group(2.066 ± 0.564) ng/L than in control group(3.750± 0.818)ng/L(P<0.01),and was also significantly lower in CI group than in plaque group(2.881 ± 0.758) ng/L(P<0.01);Serum Lp-PLA2 level was obviously higher in CI group(1.949 ± 0.666)ng/ml than in control group(1.426 ± 0.406) ng/ml(P<0.05),and was also significantly higher in CI group than in plaque group(1.703 ± 0.541)ng/ml(P<0.05);(3)The correlation between serum salusin-α level(OR=0.14,95% CI: 0.54~3.68,P<0.01) and cerebral infarction was significant in patients with unstable plaque.Conclusion:The decrease of serum salusin-α level was significantly in patients with unstable plaque; the increase of Lp-PLA2 was significantly in patients with unstable plaque.The serumsalusin-α level are possible risk factor for unstable carotid atheromatous plaque with cerebral infarction.