Correlations Between Metabolic Syndrome And Asymptomatic Intracranial Arterial Stenosis

Background: The patients with intracranial arterial stenosis had higher risk of ischemic stroke than healthy population. Under some causes, it might lead to transient ischemic attack(TIA) or ischemic stroke, then followed with different kinds of neurologic impairment symptoms or signs. Severe cases might even die. Intracranial arterial stenosis and ischemic stroke were also the risk factors for vascular dementia. Therefore, the intracranial arterial stenosis had a great harm to the patients. Compared with TIA or ischemic stroke, asymptomatic intracranial arterial stenosis was often paid insufficient attention to, although it didn’t do less harms to patients than the former. Patients with asymptomatic intracranial arterial stenosis is a very large group and had fairly high prevalence. Therefore the situations for preventing and cure ischemic stroke were rather tough. Metabolic syndrome was the risk factor for cardiovascular diseases, and also might increase the risk of ischemic stroke. But the correlations between metabolic syndrome and asymptomatic intracranial arterial stenosis had not been totally clarified. So it was necessary to make clear whether they were correlated with each other, in order to provide theoretical basis for the clinical practice.Objective: To investigate the correlations between metabolic syndrome and asymptomatic intracranial arterial stenosis.Method: During 2015 January and 2015 June, 7366 patients without ischemic stroke related history or symptoms,who underwent transcranial Doppler examination, were collected continuously as the subjects of the study in the First Affiliated Hospital of Chongqing Medical University. The subjects diagnosed as middle cerebral arterial stenosis were included in the stenosis group, while those without intracranial arterial stenosis were included into the non-stenosis group. The anthropometric indices, the biochemical indices of the subjects were measured, and the medical history were collected for the diagnosis of metabolic syndrome. Subjects with overweight or obesity, high blood pressure, dislipidemia and high glucose were included separately into groups of overweight and obesity, high blood pressure, dislipidemia and high blood glucose, while those without these abnormal indices were included separately into groups of normal weight, normal blood pressure, normal blood lipid and normal blood glucose. Moreover, according to the quantity(from one to four) of abnormal indices of every subject, all the subjects were correspondingly divided into groups of M0 to M4. The correlations between metabolic syndrome and each indices were separately analyzed in different kinds of groups.1.526 out of 7366 subjects were diagnosed as middle cerebral arterial stenosis and the prevalence was 7.1%. The prevalence of metabolic syndrome was 1.8%.2.The level of body mass index, waist circumstance, systolic blood pressure, diastolic blood pressure, total cholesterol, triglyceride, low density lipoprotein cholesterol and fasting blood glucose,and the prevalence of diabetes, hypertension and metabolic syndrome in the group of stenosis were much higher than those in the group of non-stenosis, and the differences were statistically significant(P<0.001). The difference of the level of high density lipoprotein cholesterol between the two groups were not statistically significant(P>0.05).3.The prevalence of asymptomatic middle cerebral artery stenosis in groups of overweight and obesity, high-blood, dislipidemia and high-glucose were all higher than that in the corresponding normal groups(P<0.01).4. The prevalence of asymptomatic middle cerebral arterial stenosis in group M0 was 4.2%, while prevalence in groups M1 to M4 were separately 12.9%, 24.7%, 28.2% and 31.3%, which showed tendency of gradual increase(χ2=388.769,P<0.001). With the number of abnormal indices increasing, the odds ratio of group M1 to group M4 compared to group M0 gradually increased from 3.359(95% CI:2.727~4.138),to 7.432(95% CI:5.632~9.808),8.896(95% CI:5.827~13.583), 10.293(95% CI:3.548~Results: 29.863). The differences were statistically significant(P<0.001).Conclusion: Metabolic syndrome is a risk factor of much importance for asymptomatic intracranial arterial stenosis. All the indices of overweight or obesity, high blood pressure, dislipidemia and high blood glucose were closely associated with intracranial arterial stenosis.