The New Technology Of 2-acetyl Pyrazine Synthesis

Adopting common small molecule which is commonly used in ethanol amine as the starting material,in the fixed bed equipment using ethanol ammonium intermolecular cyclization,get intermediate pyrazine,then by decarboxylation reaction with pyruvic acid and acetyl pyrazine ring of side chains,finally get the product 2-acetyl pyrazine.Acetyl pyrazine,except as a spice used in food industry,is also a very important pharmaceutical intermediates.Due to its special structure,physiological activity and reactivity,at present has been widely used in the synthesis of antibacterial,malaria,anti-tumor,anti-virus and medicines for pain,epilepsy,Parkinson’s disease,also for Heck reaction,alkylation reaction catalyst and sensitizer ligands can synthesis and the synthesis of storage materials and photosensitive material,etc.As people demand for new medicine,materials,development and utilization of acetyl pyrazine has aroused people’s attention,the development of acetyl pyrazine synthesis process has become the new subject for many enterprises to study.