The Synthesis,Crystalline Structure,Properties And Binding Interaction With Bovine Hemoglobin Of Terpyridine Zinc Complexes

The main research contents in this thesis are as follows:1.The compounds 4'-phenyl-2,2':6',2"-terpyridyl(L1),4'-(p-hydroxy phenyl)-2,2':6',2"-terpyridyl(L2),4'-(m-hydroxy phenyl)-2,2':6',2"-terpyridyl(L3),4'-(o-hydroxy phenyl)-2,2':6',2"-terpyridyl(L4),4'-(p-methoxy phenyl)-2,2':6',2"-terpyridyl(L5),[ZnL'2](p-OSO2PhCH3)2(1),[ZnL'2](N03)2(2),[ZnL12](SO3CF3)2(3),[ZnL12](SbF6)2(4),[ZnCl2L2](5),[ZnCl2L3](6),[ZnCl2L4](H2O)2(7),[ZnCl2L5](8)and[ZnBr2L5](9)were synthesized and characterized by IR,'H NMR,elemental analysis,single crystal X-ray diffraction,UV-vis spectroscopies and TG-DTA.The crystal structures of compounds L2,L4 and 7-9 were determined and they are belonging to orthorhombic(L2),rhombohedral(L4),triclinic(7)and monoclinic(8-9)crystal system.The space groups are P2(1)2(1)2(1)for L2,R-3 for L4,P-1 for 7 and P2(1)/c for 8-9.The molecular geometry is a distorted triangular bipyramidal for 7-9.The hydrogen,?-? or ?-ring were the main force of crystal cell accumulation.The photoluminescent properties of compounds L2-L4 and 1-7 were studied and they show interesting photoluminescent properties.The results show that the position of substituents and the solvents have great influence on the photoluminescence.As for the sandwich-type complexes 1-4,the peaks at the low energy region in solid states and at high energy region in solution have a intimate relationship with the values of the average hydrogen bonds in their crystal structures.The coordination modes,the anions and the diffierences in crystal packing also have marked effects on the photoluminescence of the complexes.2.The binding interactions between the compounds 4'-(p-hydroxy phenyl)-2,2':6',2"-terpyridyl(L2),4'-(m-hydroxy phenyl)-2,2':6',2"-terpyridyl(L3),4'-(o-hydroxy phenyl)-2,2':6',2"-terpyridyl(L4),[ZnCl2L2](5),[ZnCl2l3](6),[ZnCl2L4](H2O)2(7)and bovine hemoglobin were determined by molecular docking caculations,fluorescent measurements and the study of the fluorescence quenching mechanism.The results indicate that the binding process is spontaneous.The hydrogen bond interactions,van der Waals' or hydrophobic forces play important roles in this process.The fluorescent experiments show that the fluorescence of bovine hemoglobin changed regularly,as the concentrations of the compounds incerese.The main changes are the fluorescent reduction in the high energy and the red-shift of the maximum emission wavelength.The fluorescence quenching mechanism is the static quenching which depends on the formation of a complex.