Synthesis And Fungicidal Activity Of Fluorinated Quinolines And Nitrogen Containing Heterocycle Substituted Phenylamidines Derrivatives

Quinoline and amidine derivatives have been used to develop pesticide lead compounds due to their extensive biological activities.In this paper,in order to discover highly active pesticide lead structure,two types of derivatives were designed and synthesized.Firstly,different substituted anlines were used as starting material to prepare heptafluoroisopropyl substituted quinolines A1-A16 and fluorine atom substituted quinolines B1-B16.Their structures were confirmed by 1H NMR and MS.The fungicidal activities were also evaluated.The results showed that A1-A16 and B1-B16 had good fungicidal activities against Magnaporthe oryzae at the tested concentration.At the concentration of 100mg/L,compounds Al、A10、B1 and B10 showed 100%mortality against Magnaporthe oryzae,with the same effect of Tricyclazole.Secondly,four series phenlamidine compounds C1-C7、D1-D12、E1-E14 and F1-F7 were synthesized from phenylamidine and different nitrogen containing heterocyclic rings.Their structures were characterized by1H NMR and MS,and the fungicidal activities were also determined.The bioassay results showed that Cl-C7、E1-E14 and F1-F7 had different degrees of biological activity on Sphaerotheca fuliginea and Puccinia sorghi Schw.It was worthy mentioning that,at the concentration of 12.5mg/L,the inhibition rate of C2 to Sphaerotheca fuliginea was 70.11%,so it could be a potential lead compound for further research.