The Relationship Between Canine Hyperglycemia And Serum Calcium And Magnesium And Phosphorus Metabolism

Hyperglycemia is a metabolic syndrome caused by elevated blood glucose.when blood glucose concentration is higher than 7.3 mmol/L(130 mg/dL)in dogs,there are canine hyperglycemia in clinically.Hyperglycemia is an important index of diabetes,and is an important factor in the induction of diabetes and liver,kidney and cardiovascular diseases.In recent years,there have been more and more studies on the relationship between elements and the development of metabolic syndrome in the body.There have been many researches on the metabolic imbalance of elements in patients with diabetes,but the veterinary study in this area is still lacking.This paper aims to explore whether dogs suffering from hyperglycemia have the presence of serum calcium,phosphorus or magnesium metabolism abnormalities,in order to provide new ideas for the management of canine hyperglycemia and the prevention and treatment of the related secondary diseases.This paper collected the outpatient data of dogs in the past nearly 2 years from January 2015 to October 2016 in the Veterinary Medicine Teaching Hospital of Chung Hsing University in Taiwan.According to medical history,clinical examination,laboratory examination,specific examination and so on,the patients suffering from malignant tumors,osteoporosis,severe gastrointestinal diseases,ketoacidosis and severe kidney diseases were excluded.Finally,110 cases with normal blood glucose(70~120 mg/dL)and with no obvious abnormalities in the examination in dogs were set in the control group.119 cases with blood glucose concentration greater than 130 mg/dL,not diagnosed with diabetes in dogs were set in the non-diabetic hyperglycemia group.22 cases with blood glucose concentration greater than 200 mg/dL,diagnosed with diabetes in dogs were set in the diabetic hyperglycemia group.Then,according to the statistical analysis methods,the serum levels of calcium,phosphorus and magnesium in the three groups with different blood glucose levels were compared,and the correlations between blood levels of glucose and the serum levels of calcium,phosphorus or magnesium were analyzed.The results shows that the serum level of calcium in the non-diabetic hyperglycemia group was significantly lower than that in the control group(p<0.05),while there was no significant difference in the levels of serum magnesium and phosphorus between the non-diabetic hyperglycemia group and the control group(p>0.05).The serum levels of calcium and magnesium in the diabetic hyperglycemia group were significantly lower than that in the control group(p<0.05),while there was no significant in the level of serum phosphorus between the diabetic hyperglycemia group and the control group(p>0.05).In the correlation analysis,the blood glucose and serum levels of calcium or magnesium were significantly negatively correlated(p<0.05,r=-0.320,-0.152),while the blood glucose and serum level of phosphorus were positively correlated(p<0.05,r=0.124),in which the correlation between the blood glucose and serum level of calcium is the most significant.Thus,canine hyperglycemia have a metabolic abnormality of serum calcium,magnesium and phosphorus.The author believes that closely monitoring the concentration changes of serum calcium,magnesium and phosphorus have a certain guiding significance in the management of canine hyperglycemia and the prevention and treatment of various complications.Supplementation of calcium,magnesium and vitamin D may be beneficial to improving the prognosis of dogs suffering from hyperglycemia,and giving the right amount drugs promoting the excretion of phosphorus to dogs with hyperglycemia may be conducive to delay the damage of high blood glucose to the kidneys.