Association Of HLA-DQ Gene Polymorphisms With The Clinical Outcomes Of Hepatitis B Virus Infection In Chinese Han Population

Objective:To assessed the effect of the two Single nucleotide polymorphisms (rs9275572 and rs9275319) in human leukocyte antigen (HLA)-DQ gene on the clinical outcomes of HBV infection in Chinese Han population.Methods:HLA-DQ (rs9275572 and rs9275319) were genotyped in 921 subjects'by using the TaqMan probe method, including 310 HBV-related chronic liver disease patients (CLD),295 HBV spontaneous clearance subjects (SC) and 316 healthy control individuals (HC).Results:1) Rs9275572 AG genotype showed a significant protective effect on HBV clearance (P=0.001, OR,1.82,95%CI,1.26?2.62). The dominant genetic model confirmed above correlation (P=0.001,OR,1.84,95% CI, 1.30-2.61).2) SNP rs9275319 showed a significant association with HBV susceptibility and HBV natural clearance. The rs9275319 C allele play a protective role (the allele model P<0.001, OR,0.494,95% CI,0.332-0.735; the dominant genetic model P=0.001, OR,0.47,95%CI,0.31-0.72 for CLD vs HC; the allele model, P=0.024, OR,1.610,95%CI,1.065-2.434; the dominant genetic model, P=0.048, OR,1.57; 95%CI,1.01-2.48 for CLD vs SC).3) No significant difference was found in HLA-DQ locus regarding HBV-related LC or HCC.4) a conspicuous association was unveiled between haplotype T-G/T-A and HBV susceptibility or spontaneous clearance.Conclusion:HLA-DQ gene polymorphisms were correlated with HBV susceptibility or nature clearance, not the progress of the HBV related disease in Chinses Han population.