Study Of The Indexes Correlated With Bone Metabolism In Postmenopansal Women With Osteopenia

Objective: Osteoporosis is a common disease in postmenopausal women, its morbidity increases gradually along with the increase of aging process and average life expectancy. Osteopenia is the critical stage for the prevention of osteoporosis. In this research, by studying menopausal age, body composition, and the levels of serum indexes related to bone metabolism, etc, and exploring the relevance between bone mineral density and serum indexes, body composition, menopause age. we aim to find the factors affecting bone loss for postmenopausal women in osteopenia, provide them suggestions to reduce bone loss and prevent osteoporotic fractures.Methods: 80 postmenopausal women were investigated, the questionnaire included name, age, menopause time, menarche age, menstrual time, daily physical activity, sleeping quality, dietary structure, medical history, and operation history, etc. Body composition, including body mass index(BMI), body fat percentage, basal metabolic rate, height, weight, etc, bone mineral density(BMD), including the whole body, the lumbar vertebra and the left femur BMD, were all assayed by dual energy X-ray absorptiometry(DXA). The subjects were divided into normal BMD group(T-score≥-1) and osteopenia group(-2.5≤T-score<-1), according to the T-score of BMD in lumbar bone section 1-4. Fasting blood 5-10 ml. After extracting the serum, storage at-80℃ before using. Serum AKP, STRACP, TCH, TG, HDL-C and LDL-C were measured by colorimetry. Serum irisin and serotonin were measured by ELISA. By using SPSS22.0, correlation analysis between BMD and bone metabolism indexes, difference analysis of BMD, serum indicators, body composition, menopausal age between two groups.Results: 1.The level of serum indexes showed no significant difference between osteopenia group and normal BMD group. 2.In osteopenia group, the basal metabolic rate and BMI were significantly smaller than that in the normal group, there was a significant correlation between basal metabolic rate and bone mineral density, but there was no significant correlation between BMI and bone mineral density. 3.The menopausal time of osteopenia subjects was significantly higher than that of the normal group subjects, and there was a negative correlation between menopausal time and bone mineral density.Conclusions: Menopausal time is a critical factor affecting bone mineral density. Body composition also shows significant changes in postmenopausal women with osteopenia, Weight, BMI and basal metabolic rate were significantly decreased, but concentrations of serum AKP, STRACP, TCH, TG, HDL-C, LDL-C, Serotonin, and Irisin were not significantly changed during the stage of osteopenia.