Lomatogonium Different Extracts Of Pharmacological Effects Of Anti Acute Liver Injury Research

Objective: Through the Mongolian medicine Lomatogonium rotatum different extraction parts of the active site and the compatibility of pharmacological research and screening of Lomatogonium rotatum take anti-inflammatory,analgesic and anti-D-galactosamine amine acute liver damage effective active site.Methods: mice by weight is divided into a number of groups,by xylene induced ear swelling anti-inflammatory experiments,record [swelling degree=(right ear weight left ear weight)/left ear weight],[swelling inhibition rate(%)=(normal group,the mean swelling degree to give medicine group,the average swelling degree)/normal group average swelling *100%];by acetic acid writhing test,mice began writhing time and 10 points in the writhing times;the anti D-galactosamine amine acute liver in jury pharmacological experiments,detection of serum ALT,AST,observe pathological section of liver tissue.Results: Lomatogonium extraction of petroleum ether,ethyl acetate and ethanol with anti-inflammatory activity.2 Mongolian medicine Lomatogonium different extracts with different pharmacological activities,and determine the compatibility law of the active site of the liver.3.Lomatogonium ethanol parts,dichloromethane,ethyl acetate:ethanol(1:2:9)compatibility group has significant hepatoprotective activity,especially petroleum ether,ethanol(1:9)compatibility group has obvious effect of p 0.05.4.Lomatogonium effective active site compatibility group(petroleum ether: ethanol 1:9),middle dose group has significant analgesic and anti-inflammatory,hepatoprotective activity.Conclussion:1.reening of Mongolian medicine Lomatogonium analgesic and anti-inflammatory,hepatoprotective active part of the above experiment.2.Mongolian Lomatogonium different extracts with different pharmacological activities,and determine the compatibility law of the active site of the liver.3.For the screening of Mongolian medicine.Lomatogonium hepatoprotective activity site and further extraction of choleretic constituents and provide scientific basis for.