Changes Of AngⅡ In Children With Henoch-Schonlein Purpura And Its Clinical Significance

Objective:By investigating the concentration change of plasma AngⅡ(AngiotensinⅡ) in children with HSP, this study explored its role in illness monitoring of the plasma AngⅡ concentration in children with HSP and early prediction of the renal involvement on HSP condition.Methods:This research consisted 62 children with HSP(34 children without renal involvement and 28 childre with renal involvement) and 20 normal controls children.In HSP with renal involvement, there have 18 HSP with abnormal urine routine and10 HSP with normal urine routine. The disease activity scores of all HSP children were completed after hospital admission. Blood and urine samples were collected from all objects of this study to measure the concentrations of plasma AngⅡ,blood ureanitrogen(BUN), serum creatinine, urine microalbumin(MALB) andα1-microglobulin(α1-MG). The 24 hour surine samples of patients with abnormal urine routine in renal involvement group were collected to determine the 24 hours urinary protein quantity.Results:1. There were no statistical differences in age and sex structure among each group(P > 0.05).2. There were no statistical differences in the serum creatinine and serum BUN concentrations among the NC, HSP without renal involvement and HSP with renal involvement(P>0.05).3. The urine MA and urine α1-MG concentrations in group of HSP with renal involvement were significantly higher than those in groups of normal control and HSP without renal involvement(P<0.01),there was no statistical difference in urine MA and urine α1-MG concentrations between the normal control group and HSP group without renal involvement(P>0.05).4. In the acute phase,both groups of HSP with or without renal involvement had higher plasma AngⅡ concentration than that of normal control group(P<0.01),while the plasma AngⅡ concentration of HSP group with renal involvement was also obviously higher than that of without(P<0.01). In the recovery, the plasma AngⅡconcentration of both HSP groups were significantly decreased(P<0.01).5. The urine MA,urine α1-MG and plasma AngⅡ concentrations of HSP group with abnormal urine routine were all higher than those of HSP with normal urine routine(P<0.01).6. Wile the plasma AngⅡconcentration of all HSP children were positively correlated with the disease activity scores(r=0.771, P<0.01), the plasma AngⅡconcentration of HSP group with renal involvment was also positively correlated with urine MA concentration(r=0.773, P < 0.01) and urine α1-MG concentration(r=0.830, P<0.01). There was an apparent positive correlation between the plasma AngⅡconcentration of HSP with abnormal urine routine and the 24-h urinary protein quantity(r=0.832, P<0.01).Conclusions:1. AngⅡ might participated in the development process of children with HSP.2. AngⅡ could monitor the condition change of HSP children.3. AngⅡcould be employed to predict early renal injury in children with HSP,and simultaneously reflected the degree of renal involvement.