Utilizing “One-Stop” CT Perfusion And Spectral Imaging To Evaluate The Short-Term Therapeutic Efficacy Of Radio Frequency Ablation In Lung Cancer

ObjectiveThis study is to evaluate the changes of tumor in “one-stop” perfusion CT and spectral imaging before and after radio frequency ablation(RFA), and its feasibility in assessing early treatment response and predicting the prognosis in lung cancer patients. MethodThirty patients with lung cancer pathologically confirmed were undergone lung CT perfusion scan 3~5 days before and 30~45 days after RFA. The relationship of parameters(BF, BV, MTT, PS, iodine based value in arterial phase and venous phase, water based value in arterial phase and venous phase, slope rate of spectral curve in arterial phase and venous phase) changes before and after earlier RFA and efficacy of RFA were studied. ResultAfter RFA, except MTT, other parameters of all patients were decline and the changes before and after RFA of BF(t=7.340, P<0.001), BV(t=9.590, P<0.001), PS(t=2.224, P=0.034), iodine based value in arterial phase(t=8.622, P<0.001) and venous phase(t=6.608, P<0.001), slope rate of spectral curve in arterial phase(t=12.335, P<0.001) and venous phase(t=13.821, P<0.001) were statistically significant. The changes of all parameters in relieve group were more obvious than recurrence group before and after RFA, but only the BF(Z=-2.806, P=0.005), BV(Z=-3.172, P=0.002), iodine based value in arterial phase(Z=-2.806, P=0.005), iodine based value in venous phase(Z=-4.208, P=0.014) were statistically significant. Conclusion“One stop”CT perfusion and spectral imaging play an important role in assessing early treatment response in lung cancer treated by RFA.