| Objective Observe the clinical efficacy of postprandial distress syndrome of FD treated by TEA and EA,establish a scientific and effective method in the clinical treatment of FD,and explore the possible mechanisms.MethodsSelect 30 patients with PDS of FD,and divide into three groups,10 cases per group.EA group(group A)were treated by EA,every 30 min,twice a week;sham TEA and EA group(group B)were treated by EA and sham TEA,that is to say it is necessary to finish the 45 min sham TEA treatment every morning and every evening,while EA treatment;TEA and EA group(group C)were treated by EA with TEA,namely finishing the 45 min sham TEA treatment every morning and every evening,while EA treatment.It need4 weeks to finish the treatment,during the study period the patient were treated 3 times(before the treatment,after treatment 2 weekend and 4 weekend).Observe indigestion symptom scores,quality of life questionnaire(SF-36)and Zung’s anxiety and depression rating scale indicators,assess receptivity of the stomach through the liquid feeding and detect gastric electric rhythm and activity of the vagus nerve by electrogastrograph(EGG)and heart rate variability(HRV)Results 1.Indigestion symptom scores analysis: compared with before treatment,the cases of group C after treatment of 2 weeks and 4 weeks about dyspepsia symptoms total integral and postprandial full bilge,early enough,belching single symptom integral have varying degrees of declining,the differences were statistically significant(P<0.05).4 weeks after treatment,at the comparison between each group,compared with A,B groups,dyspepsia symptoms total integral and postprandial full bilge,early enough,belching single symptom integral of group C are lower,with significant difference(P<0.05).2.Quality of life scale and anxiety depression scale score analysis: Compared with before treatmentand after treatment of 2 weeks and 4 weeks,the sore of SAS and SDSof all patients of three groups has no obvious change(P > 0.05).Compared with before treatment,the score of quality of life scale of A and B groups,after 4 weeks treatment,is no significant change(P > 0.05),while patients of group C in the treatment of 4 weeks SF-36 scale has a certain degree of rise,it has significant difference(P<0.05).3.The receptivity in patients with gastric analysis: comparison between the three way,compared with before treatment,the score of threshold drink intake,after treatment in patients significantly increased(P < 0.05),the biggest drink intake changes have no statistical significance(P>0.05).Comparison between the three way,4 weeks after treatment,the threshold of group C drink intake,compared with A and B group,significantly increased(P<0.05).4.Electrogastrogram analysis: compared with before treatment, for three groups of patientsafter 2 weeks treatment,gastric slow wave ratio has no obvious change,postprandial / fasting main power ratio have different degree of rise.Among them,the postprandial / fasting main power ratio of A and B groups was no significant difference(P > 0.05),but that of group C have significantdifference(P<0.05);Compared with before treatment,4 weeks after treatment in three groups of patients,gastric slow wave ratio still has no obvious change,but postprandial / fasting main power ratio was obviously higher,the A and B groups P<0.05,C group P<0.01.5.Heart rate variability analysis:compared with the previous treatment,after 2 weeks treatment in croup C,HFhas a certain rise,LF/HF decreased,P < 0.05.Compared with the previous treatment,after 4 weeks treatment in croup C,HF increased obviously,LF/HF decreased obviously,P<0.01.Conclusion Treatment with TEA and EA can reduce clinical symptoms of postprandial discomfort syndrome of FD patients,improve their quality of life,stimulate the vagus nerve activity,regulate gastric electric rhythm,increase the receptivity of the stomach to have a purpose for the treatment of FD. |
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