Affecting Factors Analysis Of The Clinical Efficacy Of Children In Hunan Province With Allergic Rhinitis Sublingual Immunotherapy

Objective:To Analysis the Affecting Factors of the clinical efficacy of children in Hunan Province with allergic rhinitis sublingual immunotherapy and understanding of factors that influence the onset of the shortest onset time.Methods:Select 500 children with allergic rhinitis diagnosed by skin prick dust mite allergy clinics In our hospital from January 1, 2014 to September 31, 2015 included in the study,admitted to the line dust mite specific immunotherapy sublingual. Collected at the time of diagnosis in children age, gender, disease duration, nasal symptoms score, growth and development, the combined number of allergens, family history and whether the merger symptoms and other information, use dust mite drops after 1 month, 2 months, 3months, 6 months, 9 months, 1 year, 6 times in peripheral blood eosinophil count and children with nasal symptoms score, collect compliance, adverse reactions, contact history and other data during treatment; collection start at 1 year The onset time and other information. Separate the group of children to the effective and ineffective group according to symptom score improved by more than 30% of clinically effective treatment standards after treatment,and study the differeces of Group and inter-group respectively.Results : 500 children with allergic rhinitis included in the study during treatment, has a total of 102 cases for various reasons(such as the onset has been considered without further treatment, onset of treatment did not lose confidence, economic factors, etc.) termination of treatment, finally 398 cases completed 1 year of treatment, wherein the therapeutically effective children305 cases, 93 cases of ineffective treatment for children.1. Age: The effective rate in each age group are as follows: 5-7 years old group was 76.92%, from 8 to 10 years old group was 75.84%, 11 to 13 years old group was 77.27%, 14 to 16 years old group was 79.16%, age had no effect on efficiency,there is no significant difference(P> 0.05) between the groups.2. Gender: Male effective group of children accounted for 56.39%,accounting for 43.61 percent of female children; invalid group accounted for63.44 percent of male children, female children accounted for 36.56%, male children have less efficient than the treatment of female children with efficiency, the proportion of men and women between the two groups was statistically significant(P <0.05).3. Duration: Mean disease duration of the effective group was 2.1 ± 0 6years; mean disease duration of the ineffective group was 3.3 ± 0 5 years,the average duration of effective group were significantly lower than the average duration ineffective group, the difference was statistically significant(P <0.05).4. The nasal symptom score: effective group diagnosed with nasal symptoms total score of 7.97 ± 1.69, nasal symptoms diagnosed when ineffective group total score of 7.18 ± 1.53, effective group diagnosed with nasal symptoms score is higher than the ineffective group diagnosed with nasal symptoms score, the difference was statistically significant(P <0.05).5. Growth: Growth is lower than the normal group was 73.68%, normal growth and development group was 74.03%, higher than the normal growth and development group was 84.46%, higher than the normal growth and development group and the other two groups efficiently the difference was statistically significant(P <0.05), while the normal growth and development and growth lower than the normal group had no significant difference(P>0.05). Growth higher than the normal group was higher than the normal growth and development and growth lower than the normal group.6. Compliance: compliance rate of 87.14 percent effective in children,children with ineffective compliance group was 62.00%, the efficiency of the two groups was statistically significant difference(P <0.05). Effective and efficient group compliance rate is higher than the ineffective group.7. Combined allergen Number: Combine 1 allergen 63.15%,combined two allergens effective rate of 82.54%, and consolidated three or more allergens effective rate of 74.70%, three group was statistically significant(P<0.05). Due to the merger an allergen small sample size of the original group,there may be errors efficient, it is not involved in statistical difference comparing, merging two allergen combined group are more than three or more allergen group efficiency.8. Adverse reactions: the active set of adverse reactions was 1.97% in the group invalid adverse reactions was 2.15%, the difference between the two was not statistically significant by test(P> 0.05).9. History of exposure during the treatment: Effective group 3.6% of the cases the parents complained of exposure to dust mites history, 8.2% of cases contact with other allergens(such as pollen, feathers, animal fur, grasses,weeds, etc.), and the rest did not the contact allergen; invalid group 15.05%exposure to dust mites, 24.73% of the cases exposure to other allergens, and the rest are not in contact allergens. Invalid group dust mites and other allergens history of exposure was significantly higher than the original effective group, the difference between the two groups was statistically significant(P <0.05).10. Family history: an effective combined group had a family history of 15.26%, and 14.04% in ineffective group combined family history, family history and whether treatment is effective no significant relationship, no statistically significant difference(P> 0.05).11. Merge Symptoms: Merge eye symptoms(such as eye itching,tearing, etc.) effective rate of 64.44%, the combined skin symptoms(such as erythema, edema, etc.) effective rate of 44.44%, the combined effective rate of 60.00% of bronchial asthma, do not merge symptomatic group was82.33%, symptoms do not merge group was significantly higher than the other three groups(P <0.05), combined skin symptoms had the lowest efficiency.Conclusion : Hunan province children through standardized dust mite drops sublingual specific immunotherapy is a method of treating allergic rhinitis in a safe and effective treatment and the shortest onset time of 10 weeks.Sublingual specific immunotherapy in children with allergic rhinitis, various factors are as follows:The age of children, and a family history of adverse reactions or not has little influence on the therapeutic effect; Female children than male children with a good therapeutic effect,higher than normal growth and development of children more effective treatment; The longer duration,low nasal symptom score, compliance is low, combined with other allergens and more, during treatment allergen exposure history and symptoms associated with other factors will decrease the rate of effective therapeutic.