| ObjectiveTo investigate changes of mean platelet volume(MPV)in patients with essential hypertension( EH) and the relationship between MPV with EH and left ventricular hypertrophy.MethodsIn-patients with EH in our hospital between January 2013 and December 2015 were retrospectively analyzed. Normotensive healthy individuals who underwent health screening in the same period were as control group.The patients with EH were divided into two groups according to the criteria of LVH [left ventricular mass index(LVMI)?125g/m2(male) or LVMI?120g/m2(female)]: normal left ventricular group(non-LVH group) and left ventricular hypertrophy group(LVH group). The medical history, blood tests, echocardiogram parameters, MPV and other platelet indexs were recorded and compared in different groups. Bivariate analysis and multiple linear regression analysis were performed to find out the relationship between MPV and other biomarkersrespectively.Logistic regression was used to explore the relationship between MPV with hypertension and LVH.Results1.A total of 226 cases were included in this study: the hypertensive group(n=133,mean age 61.9±11.3 years,61 males72 females) and the control group(n=93, mean age 59.4±7.9years,52 males,41 females). The hypertensive patients were divided into two groups: the non-LVH group(n=61,mean age 62.1±12.0years,26 males,35 females)and the LVH group(n=72,mean age 61.8±10.8 years,35 males,37 females).2.The MPV level was significantly higher in the hypertensive group than that of control group( 8.77±0.88 vs 8.03±0.71 fl, P < 0.01), Platelet count was lower in the hypertensive group compared with the control group( 205.41±49.17vs 227.84±47.26×109/L,P<0.01).MPV level was also higher in the LVH group than that in the non-LVH group(8.96±0.91 vs 8.55±0.80 fl,P<0.01). However, there was no significant difference between the non-LVH group and the LVH group in platelet count(203.81±45.12vs207.31±53.87×109/L,P=0.68). In the different hypertensive subgroups, the MPV level was higher in the smokers compared with that of the nonsmokers(9.17±1.16vs8.65±0.74,P<0.05). Platelet count was found to be significantly higher in the female group than that in the male group(214.32±49.83 vs 194.9±46.62×109/L,P<0.05).3.MPV was found to correlate positively with systolic blood pressure(r=0.235, P<0.001), diastolic blood pressure(r=0.250, P < 0.001), LVMI(r=0.252,P=0.003),left ventricularposterior wall thickness(r=0.280, P=0.001), interventricular septal thickness(r=0.235, P=0.007) respectively and to associate negatively with platelet count(r=-0.406,P<0.001). There was no correlation between MPV and age, BMI, uric acid, creatinine, blood glucose, and other biomarkers respectively. The multiple linear regression analysis showed that LVMI and platelet count were the influencing factors of MPV.4.In the multiple logistic regression analysis, after be adjusted for age, sex, smoking and other factors, MPV was still associated with hypertension(OR=1.839; 95%CI=1.161-2.912; P<0.01) and LVH(OR=1.839;95%CI=1.161-2.912;P<0.01).ConclusionThe mean platelet volume level is increased in patients with EH.Mean platelet volume may be associated with hypertension and left ventricular hypertrophy. |
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