| Objective:Compare the coagulation parameters difference between patients with lung cancer and health people and the relationship between coagulation parameters and chemotherapy effects. Analyze the related prognostic factors which affect the lung cancer patients and establish a risk prediction model to evaluate the clinical significance of coagulation parameters in diagnosis and treatment among patients with lung cancer.Methods: We collected hospitalized patients with lung cancer in our hospital from January 2010- January 2013 with a retrospective approach. All the diagnosed and confirmed through bronchoscopy, biopsy or surgical biopsy. The sex, age, histological type, clinical stage, concomitant diseases, coagulation index and other parameters were recorded. At the same time, the relevant clinical data(sex, age, blood coagulation, blood routine examination) of health people were collected and analyszed.1. Analyze the coagulation parameters difference between patients with lung cancer and health people. 2. Analyze the difference between coagulation parameters and clinical pathology as well as chemotherapy effects in lung cancer patients. 3 Analyze the factors that influence the prognosis of patients with lung cancer and establish a mathematical model to predict the prognosis.Results: Compare lung cancer patients to healthy control group people, plasma PLT, Fib, DD levels were significantly increased and TT prolonged. The difference was statistically significant(P <0.05). 2. DD level in small cell lung cancer was higher than non-small cell lung cancer. Compare late stage patients with early stage patients, Fib, DD level were much higher. Fib, D level were much higher at lymph node metastasis patients compare to patients without lymph node metastasis.3. DD, Fib and PLT level reduced in response group after chemotherapy while the DD, Fib and PLT level did not change too much in no response group after chemotherapy. 4 Univariate survival analysis showed: the patient’s lymph node metastasis, stage, CEA, DD, PLT levels are affecting their prognostic factors. Stage and DD level are independent prognostic factors.Conclusion: Lung cancer patients with hypercoagulability are prevalence, and changes in coagulation are closely related to lung cancer staging、lymph node metastasis and chemotherapy response. Among all the factors, stage, lymph node metastasis, CEA, Fib, D-D levels are prognostic factors while stage and D-D level are independent prognostic factors. The established risk prognosis model which use prognostic index as variable can be a good individual predictor in lung cancer patients’ prognosis. |
