Analysis Of Abnormal Coagulation Parameters And Risk Factors Of Thrombosis In Patients With Non-small Cell Lung Cancer

Objective: To analyze the relationship between the coagulation parameters and clinicopathological features in patients with non-small cell lung cancer(NSCLC),and analyze the relevant risk factors of patients with venous thromboembolism(VTE).Methods: A total of 365 diagnosed patients with NSCLC were selected from the First Affiliated Hospital of Xinjiang Medical University,collected its coagulation index levels and patient-related clinical pathology data,analyze the relationship between the two.Clarified the incidence of VTE in these patients simultaneously,the clinical data and coagulation parameters of the VTE group and the non-VTE group were compared to explore possible risk factors for VTE.Results: Compared with female,the levels of APTT,PT were prolonged,the FIB level was increased in male;the D-D levels in patients?60 years were higher than <60 years;the FIB and D-D levels in patients with positive lymph node invasion were higher than in negative patients,and the APTT level was shortened;the patients with distant metastasis had higher levels of FIB,PLT and D-D than those without distant metastasis.Compared with squamous cell carcinoma patients,the FIB and D-D levels in adenocarcinoma patients were increased.Compared with patients with stage ?-?,the levels of FIB and D-D in patients with stage ?-? were increased.And 27 of them combined with VTE,found patients with distant organ metastasis,late stage,and adenocarcinoma were more likely to develop VTE.The levels of D-D and PLT in the VTE group were higher than in the non-VTE group.Conclusion: Coagulation dysfunction has a certain correlation with tumor growth and migration.NSCLC patients with distant organ metastasis,late staging,and adenocarcinoma are more likely to develop VTE.Among them,patients with higher D-D and PLT values should consider thepossibility of VTE events.