Gene Polymorphisms Associated With The Risk Of Schizophrenia In Shaanxi Han Population

Purpose:Schizophrenia is a very complicated mental disease, its main symptoms including dysfunction of feeling, perception, thinking, emotion and behavior. Previous study shown that individual genetic predisposition factors seriously affect the risk of schizophrenia. The present study aim to investigate whether single nucleotide polymorphisms of several candidate genes were associated with the risk of schizophrenia in Shaanxi Han population, which would provided a theoretical support for further studies on schizophrenia.Methods:We recruited 499 subjects who were diagnosed with schizophrenia from Xi'an Psychiatric Hospital, Shaanxi, China. The controls were 500 healthy individuals recruited from Tangdu Hospital. We selected 50 single nucleotide polymorphism (SNPs) from the analysis of published literature, and genotyped these SNPs by Sequenom MassARRAY. The chi-square test and SNPStats analysis software were used for evaluated the association between SNPs and schizophrenia.Results:Based on chi-square analysis, rs958852 (ANK3) (OR=0.749,95%CI,0.581-0.966, P=0.025), rs12573128 (TCF7L2) (OR=1.327,95%CI,1.083-1.626, P=0.006) and rs7235757(TCF4) (OR=0.823,95%CI,0.690-0.982, P=0.03) were significantly associated with risk of schizophrenia in the Shaanxi Han population. In the genetic model analyses, we found that "G/G" genotype of rs10926984, "T/T" of rs10994336, "A/A" of rs10994338, "T/T" of rs4948418 and "A/A" of rs12573128 were associated with decreased risk of schizophrenia under recessive model; "A/T-T/T" genotype of rs958852, "G/A-A/A" of rs9320010 and "A/G-G/G" of rs7235757 were associated with increased schizophrenia risk under codominate model. Additionally, we also found that "TTC" haplotype of rs10994415, rs958852 and rs16915157 on ANK3 was associated with decreased schizophrenia risk (OR=0.729,95%CI,0.536-0.991, P=0.044).Conclusions:Our results, combined with the previous studies, showed that, SDCCAG8, ANK3, TCF7L2, TCF4 may be a risk heredity factor for schizophrenia in Shaanxi Han population. Although the results we identified here need be confirmed in further studies, it shed new light on the pathogenesis of schizophrenia.