Study On Syndrome Differentiation Of Traditional Chinese Medicine In Patients With Non-Small Cell Lung Cancer Treated By EGFR-TKI

Objective:To investigate the distribution of TCM syndromes after treatment with EGFR-TKI in non-small cell lung cancer(NSCLC).To explore the deficiency and sthenia syndrome changes after the emergence of drug-resistant.To explore the relationship between PFS with deficiency and sthenia syndrome,during stage when patients receiving EGFR-TKI.In order to provide a reference for clinical syndrome differentiation.Method:In this study,76 patients with TKI-treated criteria were included.We collected with general information,clinical treatment information and TCM syndromes and other information collection of patients.Then to determine the actual situation of TCM syndrome,under the guidance of clinical Chinese medicine practitioners and predecessors.During the dtudy,I follow up o the patients and collecting the informations.Finally,using statistical knowledge to draw conclusions.Results:1.All 76 patients,the average age of 56.30±11.50 years old,mainly distributed in the 40-70 years old.The Sex,smoking history,medication time,rash and pathological type was no significant difference between the two groups(P>0.05).But the mutation sites was statistically significant(P<0.05).2.After treatment with TKI,the proportion of Qi deficiency(16.7%),the proportion of Yin deficiency(16.7%)and the ratio of phlegm-dampness(12.0%)were the main follow-up,compared with the first time,phlegm-dampness ratio(18.8%)were significantly changed,the difference was statistically significant(P<0.05).3.With the use of TKI,the proportion of patients with deficiency was increasing(10.5%,12.5%,24.1%,30.6%),while the empirical percentage continued to decline(56.6%,44.6%,34.5%,27.8%).4.To analysis the 40 TKI resistant patients,There were 4 cases diagnosed as deficiency syndrome(10.0%)and median PFS of 6 months;23 cases diagnosed as sthenia syndrome(57.5%)and the median PFS was 9 months.There was no significant difference in sex,smoking history,pathological type,rash and actual situation(P>0.05).There was significant difference between different mutation sites(P<0.01).5.During the TKI treatment,,a total of 81 adverse events were recorded.For 30 people(37%)showed as rash disease,20 people(25%)showed diarrhea,5 pelple(6%)showed as malignant or vomiting,22 people(27%)showed as loss of appetite,4 people(5%)showed as abnormal liver function.Conclussion:1.After receiving TKI treatment,the distribution of TCM syndromes was mainly composed of Qi deficiency(16.7%),Yin deficiency(16.7%)and phlegm dampness(12.0%),suggesting that in the treatment of clinical syndrome,pay attention to qi,Yin,expectorant Wet,improve the comprehensive treatment of Chinese and Western medicine.2.In patients with non-small cell lung cancer treated with EGFR-TKI,the duration of medication was prolonged by syndromes,and the evidence was mixed with the actual situation.It was suggested that.in the different stages of clinical treatment,Combined with traditional Chinese and Western medicine treatment.3.Patients with non-small cell lung cancer who underwent EGFR-TKI therapy may have a better progression-free survival than patients with deficiency.