Association Of Platelet-to-lymphocyte Ratio With The Severity Of Coronary Lesion In Patients With Acute Coronary Syndrome

Objective This study try to investigate the association of PLR with the severity of coronary lesion as assessed by the SYNTAX score in patients with acute coronary syndrome(ACS)who underwent coronary angiography.Methods A total of 118 patients with ACS and 55 patients without coronary artery disease who underwent CA were included in the study from December 2014 to April 2016.The patients with ACS were divided into 2 groups,the mild coronary lesion group with SYNTAX score ?22,n=72 and the moderate-severe coronary lesion group with SYNTAX score ?23,n=46.In all patients,venous blood samples were drawn immediately on hospital admission.Platelet count and lymphocyte count were measured by Full-automatic blood cell's analyzer,Then PLR was calculated.Baseline clinical characters and laboratory datum were compared among three groups.Correlation of PLR with SYNTAX score and predictive value of PLR for the moderate-severe coronary lesion group were examined.Results Age,gender,smoking,White blood cell count,PLR,troponin I,Hs-CRP and Creatinine were different among three groups(p <0.05).PLR was higher in the moderate-severe coronary lesion group compared with the mild coronary lesion group and the group without coronary artery disease(p <0.05).PLR was higher in the mild coronary lesion group than the group without coronary artery disease(p <0.05).In multivariate analysis,PLR that was divided into five levels,respectively <100,100-150,150-200,200-250 and 250-300,was an independent predictor of moderate-severe coronary lesion(OR 3.148,95%CI 1.886-5.254,p <0.001).There was a positive correlation between PLR and SYNTAX score.Receiver-operating characteristic curve demonstrated that the cut-off value of PLR to predict moderate-severe coronary lesion was 114.26,with 73.9% sensitivity and 64.6% specificity(area under the curve 0.714,95% CI 0.624-0.804,p <0.001).Conclusion PLR is positively correlated to the severity of coronary lesion and it is an independent predictor of moderate-severe coronary lesion in patients with ACS.