| Objective AS is lead to coronary heart disease,cerebral infarction,peripheral vascular disease and other diseases the main pathogenic factors.The disease in formed on the basis of the pathological changes of lipid metabolic disorders,begins with intimal lesion,gradual damage to the characteristics of the artery.On the basis of existing research results,this mechanism is mainly produced by caused by inflammation caused by endothelial cell injury.Granulocyte and macrophage Colony Stimulating Factor(Granulocyte macrophage Colony Stimulating Factor gm-csf)is a kind of formed by intravascular plaque in the relevant cells secrete inflammatory factors.The main risk is that affect intravascular plaque stability,more than its effect on the patchs angiogenesis reconstruction.Interleukin-37(Interleukin-37,IL a 37)can inhibit promote the production of inflammatory cytokines and mature dendritic cells(dendritic cells DCs)activation to influence the pathogenic process of atherosclerosis and its related diseases.C-reactive Protein(C Reactive Protein,CRP)of the inflammatory reaction is always involved in the process of atherosclerosis,especially in unstable plaques,especially of inflammatory activity,when intravascular plaque stabilized by inflammatory reaction also gradually reduce.This paper focuses on kidney invigorate the circulation of jiedu decoction serum gm-csf in patients with CHD,IL-37,the influence of CRP,explore its possible mechanism,trying to promote traditional Chinese medicine in the prevention and treatment of cardiovascular events in terms of theory and practice development.Method In April 2015-December in anhui traditional Chinese old heart diagnosed coronary heart disease with 40 patients with unstable angina.Using randomized grouping will study the coronary heart disease,unstable angina pectoris patients were included in the control group(conventional western medicine therapy)and group(conventional western medicine therapy with reasons of huoxue jiedu decoction on the basis of 150 ml bid)20 people.Early in the morning on an empty stomach take two groups of patients with hepatic function,renal function,blood lipids,blood glucose,blood test,blood coagulation function and related indicators,enzyme-linked immunosorbent assay(ELISA)detection in the two groups of serum gm-csf,IL-37 level,the team began to add kidney invigorate the circulation of blood day jiedu decoction 150 ml the bid.Respectively before and after the treatment period of 4 weeks,monitoring patients with liver and kidney function,blood lipids,blood coagulation function and other related indicators,collect the patient’s general condition(including age,gender,smoking history,triglycerides(Triglyceride,TG),blood lipid,Total cholesterol,Total cholesterol,TC),CRP and homocysteine(Homocysteinemia,Hcy),and other information.Enzyme-linked immunosorbent assay(ELISA)determination of two groups of patients’ serum gm-csf,IL-37 level,integral and electrocardiogram(ecg)before and after evaluation research.Using the SPSS17.0 analysis data obtained for Windows,to conform to the normal distribution of count data by chi-square test,measurement data to mean + standard deviation of the normal distribution.Think there is statistical significance when p < 0.05,p < 0.01 think has significant statistical significance.Results1,the general data in the control group(conventional western medicine therapy)20 people,with male 12,female 8 people,all the patients were between 50-79 years old,average(60.12-10.95).Group(conventional western medicine therapy with reasons of huoxue jiedu decoction on the basis of 150 ml bid)20 people,including 9 cases of male and female in 11 cases,patients age 48-78,average(60.05-10.71).In the two groups of patients gender,age,there was no statistically significant difference statistically compare(z,X~2 value were 1.16,1.16,P > 0.05).2,two groups of related biochemical indexes comparison between group TC,TG,HDL,there was no statistically significant difference LDH(t value are: 0.327,1.43,o.758,0.085,P >0.05).3,the two groups after treatment of IL-37,gm-csf,CRP expression level was significantly reduced,the difference was statistically significant(P < o.05);Group after treatment compared with the control group after treatment of IL-37,gm-csf,CRP expression level slightly lower,statistically significant difference(P < o.05).The two groups before treatment IL-37,gm-csf,CRP expression level difference is no statistical significance(P > 0.05).Conclusion Treatment after liver and kidney function,blood lipids in patients with no significant changes in blood sugar,blood coagulation function of serum gm-csf,IL-37,CRP levels are significantly lower than before treatment.Kidney invigorate the circulation of jiedu decoction combined conventional western medicine therapy can inhibit serum gm-csf,IL-37,elevated CRP expression.Can better inhibit inflammation factor expression,Increase plaque stability,suppress the AS process,reduce the occurrence of CHD. |
