A Preliminary Study On The Relationship Among Different Symptoms Of The Duodenal Ulcer,HP And Pepsinogen

ObjectiveThe research explore the relationship between the different symptoms of the duodenal ulcer(DU),Helicobacter pylori(HP)and pepsinogen(PG)to improve the clinical curative effect of Traditional Chinese Medicine(TCM)and treatment of DU.Methods(1)Over 100 cases who had been diagnosed as active stage(A stage)of DU,were collected with inclusion and exclusion criteria in Guangdong Province Hospital of Integrated Traditional Chinese and Western Medicine from March 2015 to December 2016.(2)Collected and recorded the normal information,different syndromes,gastroscope reports,testing results of HP,the level of PG Ⅰ and PGⅡ.(3)Mainly observed the different syndromes,testing results of HP,the level of PG Ⅰ and PGⅡ,and all the data were analysed by statistics of SPSS 22.0.The research was a retrospective study.Results1.There were 139 cases collected with inclusion and exclusion criteria,which were 57 cases(41.0%)of deficiency cold of spleen and stomach syndrome,31 cases(22.3%)of spleen-stomach damp-heat syndrome,30 cases(21.6%)of liver-stomach disharmony syndrome,11 cases(7.9%)of yin deficiency of stomach syndrome and 10 cases(7.2%)of static blood in stomach collaterals syndrome.Different syndromes had no significant difference in sex and age(P>0.05),but had significant difference in course of disease(P<0.01).The deficiency cold of spleen and stomach syndrome,liver-stomach disharmony syndrome,the damp heat in the spleen and the stomach syndrome respectively had significant difference with the other syndrome in course of disease(P=0.000<0.0083),and their course was shorter than the other syndrome.2.The relationship between HP and different syndromes:the positive rate of spleen-stomach damp-heat syndrome(84.2%)was highest in all syndromes.Through statistical test,the positive rate of each syndrome was no significant difference(P>0.05).3.The relationship among PGⅠ、PGⅡ and TCM syndromes:There was significant difference among all syndromes in the level of PG Ⅰ(P=0.000<0.01).The deficiency cold of spleen and stomach syndrome,liver-stomach disharmony syndrome,the damp heat in the spleen and the stomach syndrome respectively had significant difference with the other syndrome in the level of PG Ⅰ(P=0.000<0.0083),and the level of PG Ⅰ were also higher than the other syndrome.There was no significant difference among all syndromes in the level of PGⅡ(P=0.310>0.05).4.Binary logistic regression analysis of TCM syndromes:The deficiency cold of spleen and stomach syndrome had no difference with sex,age,the course of disease,HP,the level of PG Ⅰ and PGⅡ(P>0.05).While the level of PG I had positive correlation with liver-stomach disharmony syndrome(P=0.013<0.05).When the level of PG Ⅰ increased 1 ng/ml(OR=1.011,95%CI-1.002-1.020),the patient being liver-stomach disharmony syndrome would increased 1.011 times.The level of PG I had negative correlation with the damp heat in the spleen and the stomach syndrome(P=0.021<0.05).When the level of PG I decreased 1 ng/ml(OR=0.989,95%CI=0.980-0.998),the patient being the damp heat in the spleen and the stomach syndrome would increased 0.989 times.Conclusion1.The active stage(A stage)of DU has a certain rule in TCM syndromes which are mainly deficiency cold of spleen and stomach syndrome,liver-stomach disharmony syndrome and the damp heat in the spleen and the stomach syndrome.2.Different syndromes have no influence with sex and age,but have significant difference in course of disease.There would be yin deficiency of stomach syndrome and static blood in stomach collaterals syndro-me when the course of disease increases.3.It can’t be concluded that different syndromes of the active stage(A stage)of DU have relationship with HP,and it needs further study with more sample size.4.Different syndromes have close relationship in the level of PG I but not in the level of PGⅡ If the level of PG Ⅰ is higher than normal,it is mainly in the deficiency cold of spleen and stomach syndrome,liver-stomach disharmony syndrome and the damp heat in the spleen and the stomach syndrome.If the level of PG I is lower than normal,it is mainly in the yin deficiency of stomach syndrome and static blood in stomach collaterals syndrome.The level of PG Ⅰ could be one of the clinical references in the syndrome differentiation of the active stage of DU,which is worth deeper researching.5.Liver-stomac.h disharmony syndrome and the damp heat in the spleen and the stomach syndrome have something to do with the level of PG I.There is an increased risk of being classified as liver-stomach disharmony syndrome as PG Ⅰ increases.There is an increased risk of being classified as the damp heat in the spleen and the stomach syndrome as PG I decreases.