The Analysis Of The Causes Of The Fetal Growth Restriction

Background and ObjectiveFetal growth restriction(FGR),also known as intrauterine growth retardation(IUGR),refers to the fetus in the womb for all kinds of bad reason cannot reach its growth potential,Show the fetal weight in with same gestational age below the tenth percentile or below 2 standard deviations of average fetal weight.The investigation statistics of Epidemiology found that the incidence of FGR is 2.75% ~ 15.53%.The incidence of developing countries is 11.2%,which is 6 times that of developed countries.According to the statistics,the incidence of FGR in China is about 6.39%.Which is a common one of the serious complications of obstetrics,and greatly increases the morbidity and mortality of perinatal fetal and neonatus.FGR is one of the leading cause of premature birth,mortality rate in the perinatal period can reach 4 ~ 6 times that of the normal fetus.In the cause of perinatal fetal death in China,FGR accounts for 42.3%,is the second factors of death in newborn babies.FGR can not only cause perinatal fetal and neonatal adverse outcomes,also affects their profound outcomes.The cause of FGR is complex,and has not yet been completely clear.In this article,we select the pregnant women between April 2015 and March 2016 in our hospital,and retrospectively analyze their medical records.Our objective is to study how the maternal factors influence the fetal intrauterine growth,so as to provide evidence for the prevention and control of FGR.Date and Method1.DataWe collected the medical records of all singleton pregnancy who were in our hospital during the period of April 2015 to March 2016,and confirmed the live births as FGR according to the fetal birth weight was10 th percentile lower than gestational age.Divided all pregnancies into groups according to age < 25 years old,25 ~ 35,35 years old;whether primipara or not;Normal weight gain during pregnancy or excessive or insufficient;whether HDCP or not;whether proteinuria or not;whether anemia or not;whether diabetes or not;whether umbilical cord blood flow change or not;whether low amniotic fluid volume or not;whether abnormal placenta or not.Calculated the number of analysis indicators and the number of cases of FGR.Excluded multiple pregnancies,stillbirth,birth defects and maternal uterine malformation,to ensured the representative and reliable data.Diagnostic criteria:reference the 8th edition of 《Obstetrics and Gynecology》which published by People,s Medical Publishing House.2.Statistical analysis methodStatistical analyses were performed using the computer software SPSS statistics version 19.0.The count datas were compared by chi-square test between two groups,and independent influencing factors were performed by logistic stepwise regression analysis.A p value of <0.05 was considered statistically significant.Results1.There were 140 cases of FGR in 2150 cases of singleton live birth newborn.The incidence of FGR was 6.51%.2.The analysis of influencing factors:Insufficient weight gain during pregnancy,HDCP,proteinuria,umbilical cord blood flow change and low amniotic fluid volume had statistical correlation with FGR(P< 0.05).We did not found that age of pregnant women,whether primipara or not,anemia,diabetes and abnormal placenta had statistical correlation with FGR(P> 0.05).3.Multivariable Logistic regression analysis showed that insufficient weight gain during pregnancy,HDCP,proteinuria,and low amniotic fluid volume were independent influencing factors of fetal growth restriction(P < 0.05).Conclusions1.The incidence of FGR is 6.51% in our hospital,which is consistent with the known research.It shows our hospital’s incidence of FGR is at the national average.2.Insufficient weight gain during pregnancy,HDCP,proteinuria,umbilical cord blood flow change and low amniotic fluid volume have statistical correlation with FGR.We don’t found that age of pregnant women,whether primipara or not,anemia,diabetes and abnormal placenta have statistical correlation with FGR.3.Insufficient weight gain during pregnancy,HDCP,proteinuria,and low amniotic fluid volume are independent influence factors of neonatal birth weight.We should strengthen the monitoring and treatment for the pregnancy with above abnormal factors.