Application Of Continuous Blood Purification In Multiple Organ Dysfunction Syndrome

BackgroundContinuous blood purification(CBP)can remove some of the pathogenic substances by diffusion,convection,and adsorption to treat disease.CBP is in line with the physiological state,it can effectively improve the immune function of patients,can constantly adjust the balance of the liquid according to the needs,through the adsorption,convection mechanism,clear the blood of inflammatory mediators and solutes,this gives it a high clearance rate,so CBP has a significant effect on multiple organ dysfunction syndrome(MODS).ObjectiveTo investigate the effect of continuous blood purification in patients with multiple organ dysfunction syndrome by the retrospective analysis of clinical routine treatment received continuous blood purification treatment of MODS patients with only routine clinical treatment and did not accept the comparison of continuous blood purification treatment of MODS patients before and after treatment the clinical index.MethodsWe selected 60 patients admitted to Nanyang City Central Hospital from January 2014 to September 2016,who were presented with MODS and received clinical routine treatment and continuous blood purification treatment,those patients were divided into group A;We selected another 60 patients admitted to Nanyang City Central Hospital from January 2014 to September 2016,who presented with MODS and only received clinical routine treatment,those patients were divided into group B.To observe the Marshall score,blood urea nitrogen(BUN)and electrolyte levels(K+),serum creatinine(Scr),carbond ioxide combining power(CO2CP),N terminal pro brain natriuretic peptide(NT-proBNP)and the success rate of treatment and hospitalization days in Intensive care unit(ICU)before and after treatment in two groups.Results1.Compare group A and B before treatment with Marshall score,blood urea nitrogen,electrolyte levels,serum creatinine,carbon dioxide combining powerand N terminal pro brain natriuretic peptide,all the data were analyzed by independent sample T test,P>0.05,the difference was not statistically significant.2.Compare the patient of group A and B after treatment with Marshall score,blood urea nitrogen,electrolyte levels,serum creatinine,carbon dioxide combining power and N terminal pro brain natriuretic peptide,and hospitalization days in Intensive care unit,all the data were analyzed by independent sample T test,P<0.01,the difference was statistically significant.3.Compare the data of Marshall score,blood urea nitrogen,electrolyte levels,serum creatinine,carbon dioxide combining powerand N terminal pro brain natriuretic peptide of the patient before treatment in group A,all the data were analyzed by paired sample T test,P<0.01,the difference was statistically significant.4.In the MODS patients who were treated with continuous blood purification,43 cases were cured(71.7%),17 cases were dead(28.3%);In the MODS patients who were not treated with continuous blood purification,19 cases were cured(31.7%),41 cases were dead(68.3%),the data is analyzed by chi square test,P<0.01,the difference was statistically significant.5.In group A,the total time of CBP treatment ranged from 22 to 90 hours,and the average duration of CBP was about 43.82 ± 16.10 hours.Conclusion 1.On the basis of routine clinical treatment,early continuous blood purification therapy can effectively improve the condition of patients with multiple organ dysfunction syndrome.2.Continuous blood purification therapy is effective in the treatment of multiple organ dysfunction syndrome,it can improve the patient's condition,reduce the mortality of patients,accelerate the rehabilitation of patients,has important significance,CBP has important clinical application and popularization value.