Clinical Study On Treatment Of Ulcerative Colitis(Active Period) Based On The Theory Of "Heat Toxin Impairing Intestine Collateral"

Object: Observe the clinical efficacy of the method of oral Detoxification Ning luo decoction combine with colonic instillation of skullcap vine Anchang Tang to the treatment of ulcerative colitis(UC)active period to explain the pathogenesis of UC is the theory of "Noxious heat damage intestinal envelope",and to provide new ideas and methods for clinical treatment of ulcerative colitis.Methods:60 patients with active ulcerative colitis were selected according to the inclusion criteria and randomly divided into two groups,In the experimental group,30 cases were treated with oral Detoxification Ning luo decoction combine with colonic instillation of skullcap vine Anchang Tang,The control group of 30 cases were given mesalazine orally.Two groups were treated with a total of two courses.After two courses of treatment,the curative effect was evaluated.Followed up 1 times a month,a total of two times and statistics recurrence.SPSS21.0 statistical software was used to analyze and compare the data.Results:(1)Comprehensive effect:Using rank sum test it can be infer that the experimental group(total effective rate 90%)was significantly better than the control group(total effective rate 76.67%)(P<0.05).(2)efficacy:The test group was better than the then purulent or bloody diarrhea,abdominal pain,tenesmus,fever,thirst and other symptoms in the control group(P<0.05),while the effect of abdominal distension,yellow urine Chideng symptoms have no significant difference between two groups.(3)Total score of TCM symptoms:The experimental group was better than the control group(P<0.05).(4)Syndrome curative effect:Using rank sum test it can be infer that the experimental group(total effective rate 93.33%)was better than the control group(total effective rate 76.67%)(P<0.05).(5)Effect of colonoscopy: The experimental group was better than the control group in the improvement of total endoscopic score after treatment(P<0.05),demonstrate that the experimental group was better than the control group in the effect of colonoscopy.(6)The effect of Mucosal histopathology: The experimental group was better than the control group in the improvement of total score of mucosal histopathology(P<0.05),demonstrate that the experimental group was better than the control group in the effect of total score of mucosal histopathology.(7)The effect of Serum C-reactive protein(CRP): The experimental group was better than the control group(P<0.01).(8)The effect of erythrocyte sedimentation rate(ESR):The experimental group was better than the control group(P<0.01).(9)The effect of Serum D-two polymer:The experimental group was better than the control group(P<0.01).(10)Recurrence rate:The experimental group was lower than the control group,there has no statistical significance through X2 test.Conclusion: The clinical efficacy of the method of oral Detoxification Ning luo decoction combine with colonic instillation of skullcap vine Anchang Tang to treatment of ulcerative colitis(UC)active period(Mild moderate,Noxious heat accumulation,poison damage intestinal envelope)has a significant effect both in the clinical efficacy and improvement of biochemical indicators.However,there is no obvious advantage in preventing recurrence.Therefore,the method of oral Detoxification Ning luo decoction combine with skullcap vine Anchang Tang enema is the effective prescription to the treatment of ulcerative colitis(UC)active period(Mild moderate),which syndrome type is Noxious heat accumulation,poison damage intestinal envelope).