Clinical Research Of Intraoperative Submucosal Multiple Injection Of Interleukin-2(IL-2) And Intravesical Instillation Of Gemcitabine(GEM) In The Treatment Of Non-muscle-invasive Bladder Cancer(NMBIC) During Transurethral Resection Of Bladder Tumor(TUR-Bt

Objective:1 To observe and discuss the effect of a clinical research,which is related about NMIBC by intraoperative submucosal multiple injection of IL-2 and intravesical instillation of GEM within 24 hours after TUR-Bt.2 To analysis patients with different-risk recurrence rate by accepting intraoperative submucosal multiple injection of IL-2 and only doing traditional TUR-Bt.Methods:128 cases of NMIBC were collected from February,2013 to February,2015.76 males and 52 females,aged from 26 to 81 years old,with an average age of 58.7 years.Randomly divided into 2 groups: experimental group and control group.The experimental group had 68 cases.During TUR-Bt,surgeon multiply injected IL-2 to bladder submucosa and tumor basilar part;There are 60 cases in Control group,the patients only accepted TUR-Bt.Both groups were infused with GEM in 24 hours after operation.When cystoscopy was performed,every three months,the experimental group received multiple injection of IL-2 again and the control group did not do any treatment.In follow-up period,the recurrence rate of bladder tumor in two groups was compared.Results:All cases were followed up for 2 years.The recurrence rate of bladder tumor in experimental group was lower than that in control group(p <0.05),and it has statistical significance.According to the postoperative pathology of the tumor and the score of recurrence risk,the patients was further divided into 3 kinds of groups:Low risk,Moderate risk,High risk.The recurrence rate between experimental group and control group was statistically analyzed,and there is no difference between the recurrence rate of experimental group and control group respectively in low or moderate risk group(p > 0.05);As for high risk patients,The recurrence rate of bladder tumor in experimental group was lower than that in control group(p < 0.05).Conclusions:The treatment,combined intraoperative submucosal multiple injection of IL-2 and intravesical instillation of GEM,is effective to prevent recurrence of bladder cancer especially for high-risk patients with NMIBC.This method is simple,high safety,less side effect and has good clinical value.