Research Progress Of The Effect Of Thiazolidinediones On Bone Metabolism

Thiazolidinediones(TZDs)are agonists of the peroxisome proliferator-activated receptor gamma(PPAR-γ),which can exert insulin-sensitizing effects.At present rosiglitazone and pioglitazone are the most commonly used TZDs.TZDs can improve the management of hyperglycaemia in Type 2 diabetes and may regulate lipid metabolism.As patients with Type 2 diabetes need long time treatment,any potential risk of these agents need to be considered.Some large-scale randomized controlled trials and observational studies reported that TZDs may contribute to bone loss and an increased risk of fracture.In this article the effects of thiazolidinediones on bone metabolism and its possible mechanisms will be reviewed.