The Study Of Correlationship Between Serum Sodium,Fractures And Bone Mineral Density

Introduction Hyponatremia,as the most common electrolyte disorder,had been linked to the neuromotor deficits affecting gait stability lead to falls even fractures and directly affects the bone metabolism lead to osteoporosis.But few studies had focused on patients with spinal fracture or spinal degenerative disease,and did not consider the potential confounders like anemia,hypoalbuminemia.Therefore,we conducted this study to further explore the relationship between serum sodium,fractures and bone mineral density.Methods In this cross-sectional study,we take the patients with spinal fractures(including cervical,thoracic,lumbar fractures and traumatic vertebral dislocation)and spinal degenerative disease(including cervical spondylosis,spinal stenosis,disc herniation,degenerative spinal deformity)as the research object,considering comorbidities,medications,anemia,hypoalbuminemia and other confounding factors,to evaluate the relationship between serum sodium,fractures and bone mineral density.Results Hyponatremic patients had a significantly higher prevalence of fractures,and lower BMD and T-scores at lumbar spine,femoral neck and total hip.Adjusted for the potential confounding factors,hyponatremia also was an independent risk factor for fracture(OR=2.618,95%CI [1.831-3.743],p < 0.001)and osteoporosis(OR=2.380,95%CI [1.646-3.441],p < 0.001).The subject with falls was more likely to have a significantly lower serum sodium,compared with the patient with traffic injuries or smash/crush injuries(p < 0.05).The T-score of lumbar spine,femoral neck and total hip has a significantly linear correlation with serum sodium values respectively(p < 0.001).Conclusion Our research provides a evidence that hyponatremia is an important independent risk factor for osteoporosis and fractures caused by falls,and the T-score of lumbar spine,femoral neck and total hip has a significantly linear correlation with serum sodium values respectively.Serum sodium monitor might be a simple tool for prediction of fracture risk and osteoporosis screening.