The Influence On The Immune Function Of Microwave Ablation Intreatment Of Primary Hepatocellular Carcinoma

Objective To investigate the number and function of partial immune indexes after percutaneous microwave ablation and discuss the effect of microwave ablation on immune function in peripheral blood in patients with primary hepatocellular carcinoma,in order to provide an objective basis for the treatment.Methods A total of 48 patients with primary hepatocellular carcinoma were selected for the study.All the patients were treated with percutaneous microwave ablation.T cell subsets,Natural killer cell,IFN-?,TNF-?,IL-12,IL-2,IL-10,IL-4,IL-1?,IL-6,IL-8,IP-10,MCP-1/MCAF,IL-17 as well as liver function determined before 3d,8d and 1mo after the cancerous node were ablated,and compare the changes of AFP.Results 1.Compared with preoperative group,the percentage of NK cell increased significantly and the percentage of IL-8 decreased significantly at day 8 after microwave ablation(P= 0.004,0.028).2.The percentage of NK cell,IL-12,IFN-?,TNF-?,CD4+/CD8+ increased significantly(P= 0.0004,0.028,0.043,0.018,0.035)and the percentage of IL-4,IL-6,CD4+ CD25+ T cell decreased significantly at one mouth after microwave ablation(P= 0.019,0.008,0.0003).3.The changes of AFP before and after the treatment decreased significantly(t=2.39,P<0.05).4.The changes of all the immune parameters between the 8t h day and the 30 t h day after treatment were no statistical significance(P>0.05).Conclusion 1.Percutaneous microwave ablation of tumor resulted in reducing the number of regulatory T cells and IL-4;however,increasing the percentage of NK cell,IL-12,IFN-?,TNF-?,CD4+/CD8+,which suggested the immunity function of body would be improved when the tumors were treated with microwave ablation.2.IL-8,IL-6 decreased significantly after ablation,which showed that percutaneous microwave ablation for primary hepatic carcinoma could reduce tumor loading and offer significant short-term effects.