Study On Prevalence And Correlates Of Hyperuricemia In Type 2 Diabetic Patients

Objective: The study aimed to investigate the epidemic status and correlates of hyperuricemia among the inpatients with type 2 diabetes mellitus(T2DM),which will provide theoretical basis for the clinical application in prevention of hyperuricemia.Methods: A retrospective review was conducted in Tianjin Metabolic Disease Hospital from January 1,2008 to March 1,2013 extracting relevant information of medical records.A total of 2178 patients with T2 DM who had known blood uric acid or blood uric acid test were included in this research,the prevalence and clinical features of hyperuricemia among the patients with T2 DM were analyzed.A case-control study was conducted,in which T2 DM patients with hyperuricemia were as cases and T2 DM patients with normal uric acid were as controls,to analyze correlates of hyperuricemia patients and compared with the control group,and then to analyze correlates of hyperuricemia among T2 DM patients by non-conditional Logistic regression.Results:1.Among 2178 inpatients with T2 DM,318 patients had hyperuricemia.The prevalence of hyperuricemia in T2 DM patients was 14.6%,and the prevalence of hyperuricemia was higher in female T2 DM patients(17.6%)than that in males(12.2%)(P<0.001).The prevalence of hyperuricemia increased with age and duration of T2 DM patients.2.Total of 318 T2 DM with hyperuricemia were selected as case group and 1860 T2 DM with normal uric acid as control group.The results of univariate logistic regression analysis showed that female,older age,retirement,longer duration of diabetes,insulin treatment,obesity,high serum triglycerides,abnormal UMA,abnormal CRP,diabetic retinopathy,diabetic nephropathy,hypertension,coronary heart disease,dyslipidemia,hyperfibrinogenemia and the CHD family history were associated with higher odds of hyperuricemia,and higher haemoglobin A1c(Hb A1c)level was associated with lower odds of hyperuricemia among T2 DM patients.After adjustment for potential confounders,female,older age,retirement,longer duration of diabetes,obesity,high serum triglycerides,abnormal UMA,abnormal CRP,diabetic retinopathy,diabetic nephropathy,hypertension,coronary heart disease,dyslipidemia,hyperfibrinogenemia and the CHD family history were associated with higher odds of hyperuricemia,and higher haemoglobin A1c(Hb A1c)level was associated with lower odds of hyperuricemia.The associations of the risk of hyperuricemia with marital status,nation,FBG,TC,HDL-C,LDL-C,smoking,drinking,oral medicine,the family history of DM,gout and hypertension and other diabetes complications,etc were not found in the prenset study.3.The results multivariate non-conditional logistic regression analysis showed that obesity,higher Hb A1 c level,female,diabetic nephropathy were related to hyperuricemia in type 2 diabetic patients.Their ORs and 95%CIs were 1.795(1.474-2.185),0.534(0.433-0.660),1.658(1.247-2.204)and 2.790(2.094-3.718),respectively.Conclusion: The prevalence of hyperuricemia among T2 DM inpatients was 14.6%,and the prevalence of hyperuricemiawas significantly higher in females than that in males and increased with age and duration of T2 DM inpatients.Female,obesity,and diabetic nephropathy were associated with higher risk of hyperuricemia,while higher Hb A1 c level was associated with the lower odds of hyperuricemia in type 2 diabetic patients.