Association Between Lipid Levels And Depressive Symptoms In Physical Examination Population In Tianjin

ObjectiveBased on participants from health management centre of Tianjin medical university general hospital,we designed a cross-sectional study to investigate the relationships between lipid levels and prevalence of depressive symptoms in physical examination population in Tianjin.MethodsWe analyzed the baseline data from The Tianjin Chronic Low-grade Systemic Inflammation and Health(TCLSIHealth)Cohort Study.A cross-sectional analysis was conducted with 16,955 general adults who underwent the annual health check in Health Management Center of Tianjin Medical University General Hospital.Investigators collected the questionnaires and physical examination data.Depressive symptoms was assessed using the Chinese version of 20-item Self-rating Depression Scale(SDS)with 1 cut off(48)to indicate elevated depressive symptoms.Logistic regression and analysis of variance was used to describe the characteristics of depressive symptoms,as well as different lipid categories.Depressive symptoms was used as dependent variables,and lipid categories were used as independent variables.Multiple logistic regression analysis was used to examine the relationships between lipid categories and depressive symptoms.During the analysis,study population was stratified into different groups according to gender.ResultsIn the study population,the prevalence of SDS ?48 was 9.55%.In males,it was 9.17%.In females,it was 10.05%.Females have higher prevalence than males(P <0.05).In the study population,after adjusted for multivariate variables,the prevalences of depressive symptoms are higher in the second categories of TC than in the first category of TC,the adjusted OR(95% CI)for depressive symptoms across TC categories were 1.00(reference),1.22(1.02,1.46),1.11(0.88,1.39)and 1.25(0.94,1.66)(P for trend =0.144),the prevalences of depressive symptoms are lower in the second categories of LDL-C than in the first category of LDL-C,the adjusted OR(95% CI)for depressive symptoms across LDL-C categories were 1.00(reference),0.82(0.69,0.97),0.83(0.68,1.03)and 0.87(0.67,1.13)(P for trend =0.224),and the prevalences of depressive symptoms are lower in the third categories of HDL-C than in the first category of HDL-C,the adjusted OR(95% CI)for depressive symptoms across HDL-C categories were 1.00(reference),0.90(0.78,1.05),0.79(0.67,0.93)and 0.87(0.73,1.04)(P for trend =0.060).In males,after adjusted for multivariate variables,the prevalences of depressive symptoms are lower in the second categories of LDL-C than in the first category of LDL-C,the adjusted OR(95% CI)for depressive symptoms across LDL-C categories were 1.00(reference),0.76(0.60,0.96),0.88(0.66,1.17)and 0.97(0.68,1.38)(P for trend =0.874).In females,after adjusted for multivariate variables,the prevalences of depressive symptoms are higher in the third and fourth categories of TC than in the first category of TC,the adjusted OR(95% CI)for depressive symptoms across TC categories were 1.00(reference),1.29(0.99,1.69),1.42(1.02,1.98)and 1.53(1.01,2.35)(P for trend =0.025),the prevalences of depressive symptoms are lower in the third categories of HDL-C than in the first category of HDL-C,the adjusted OR(95% CI)for depressive symptoms across HDL-C categories were 1.00(reference),0.84(0.68,1.04),0.59(0.46,0.76)and 0.86(0.66,1.11)(P for trend =0.107).ConclusionsThe study showed that higher TC was associated with higher prevalence of depressive symptoms in females,and the prevalences of depressive symptoms are lower in the third categories of HDL-C than in the first category of HDL-C.The prevalences of depressive symptoms are lower in the second categories of LDL-C than in the first category of LDL-C.More studies are needed to demonstrate the results.