The Clinical Observation Of Descending Turbidity Tang Treatment On The Type Of Spleen-kidney Qi Deficiency And Dampness-heat Of Chronic Glomerulonephritis

Objective: Observe the clinical curative effect of Descending Turbidity Tang treatment on chronic glomerulonephritis with spleen-kidney qi deficiency and dampness-heat type.To test the concentration of TGF-?1(Transforming growth factor-beta 1)in blood of patients which is influenced on Descending Turbidity Tang with spleen-kidney qi deficiency and dampness-heat syndrome of chronic glomerulonephritis.To investigate the mechanism of "Descending Turbidity Tang" in treating chronic glomerulonephritis from regulating immunity and retarding glomerulosclerosis.Methods: 1.The study observed 60 cases of chronic glomerulonephritis with spleen-kidney qi deficiency and dampness-heat type in clinical.All 60 cases of patients with chronic glomerulonephritis were randomly divided into treatment group and control group,in which group included 30 cases and belongs to the type of spleen-kidney qi deficiency and dampness-heat syndrome,both of which are based on routine treatments of western medicine.The the control group was given Nephritis rehabilitation tablets and Tripterygium glycosides oral treatment of TCM,while treatment group was given Descending Turbidity Tang oral treatment of TCM.The two groups both were treated for 8 weeks.There were no statistical differences in age,gender,course of disease,etc.2.Observe the change of laboratory indicators such as Blood routine ? Complement 3(C3)?Complement 4(C4)?Liver function?Blood lipids?Renal function? Electrolyte ? 24 h urine protein quantitation(24h UTP)? C-reactionprotein(CRP)?Transforming growth factor-beta 1(TGF-?1)and then compare the treatment results and judge the difference of the curative effect.3.Observe the changes in TCM symptoms in the two groups of patients,and quantify the TCM syndrome scores,then analyze the effect.Results: The study plans to investigate 64 cases and actually investigate 60 cases.There are 4 cases in the process of rejection and shedding,and 30 cases in the experimental group and the control group,the test group and the control group were 30 cases respectively.1.Comparison of the total clinical efficacy: after treatment,the total effective rate of the treatment group is obviously greater than that of the control group when the difference was statistically significant(P<0.05)by comparing the treatment group to the control group.2.Improvement of Complement 3(C3)?Complement 4(C4),blood lipids,kidney function and 24 h UTP: the improvement of Complement 3(C3)?Complement 4(C4),blood lipids(CHOL?TG ?L-DLC ?H-DLC)),uric acid(UA)of the treatment group is better than that of the control group when the difference is statistically significant(P<0.01)by comparing the laboratory indicators in treatment group to the control group after treatment;the improvement of 24 h UTP of the treatment group is better than that of the control group when the difference is statistically significant(P<0.05)by comparing the laboratory indicators in treatment group to the control group after treatment.3.Comparison of TGF?-1 and CRP: the improvement of TGF?-1 and CRP of the treatment group are better than that of the control group when the difference is statistically significant(P<0.01)by comparing the laboratory indicators in treatment group to the control group after treatment.4.Comparison of the total effect of TCM: the total effect of TCM in the treatment group is better than that in the control group when the difference is statistically significant(P<0.05)by comparing the treatment group to the control group after the treatment.5.Comparison of the efficacy of TCM symptoms: the efficacy of TCM symptoms in the treatment group is better than in the control group when the difference is statistically significant(P<0.05 or P<0.01).Conclusion: Descending Turbidity Tang can effectively improve the clinical symptoms of patients with spleen-kidney qi deficiency and dampness-heat syndrome of chronic glomerulonephritis,and reduce serum TGF?-1 and CRP levels,especially for the symptoms of traditional Chinese medicine.It is suggested that Descending Turbidity Tang may regulate the immune disorder and suppress inflammation of patients with spleen-kidney qi deficiency and dampness-heat syndrome of chronic glomerulonephritis by reducing serum TGF?-1 and CRP levels,so as to improve symptoms and delay the progression of chronic kidney disease.