Clinical Observation On Using The Method Of Yishenjianpi To Intervene In Thyroid Function And PAPPA Level Of Patients With Early-stage Threatened Abortion Combined With Subclinical Hypothyroidism

Objectives:This topic aimed to use the standardized clinical observation on recording and analyzing the clinical effect using the method of yishenjianpi to intervene in early-stage threatened abortion combined with subclinical hypothyroidism.By monitoring patients’ serum PAPPA changes,the study explored the significance of PAPPA in threatened abortion combined with subclinical hypothyroidism.Methods:60 patients with early-stage threatened abortion combined with subclinical hypothyroidism were collected and divided into two groups.The patients in the treatment group were intervened by Hutaiyin oral liquid+ dydrogesterone(29 patients),while patients in the control group were intervened by dydrogesterone(31 patients).Two weeks were used as a course of treatment.Observation time was 2 courses of treatment.Symptom changes of two groups before and after intervention were observed.Patients’serum β-human chorionic gonadotropin(β-HCG),progesterone(P),thyrotropic hormone(TSH),free thyroxine(FT4),thyroid peroxidase antibody(TPOAB)and pregnancy associated plasma protein A(PAPPA)before and after treatment were respectively detected for intra-class contrast and interblock contrast.Meanwhile,relevant pregnancy outcome of patients was conducted follow-up visit for interblock contrast.Results:1.The method of yishenjianpi not only could significantly improve patients’ clinical symptoms,but also could effectively reduce patients’ serum TSH and increase serum FT4 and PAPPA.Meanwhile,there was no significant influence on TPOAb.For the interblock contrast after intervention of HCQ P,TSH and PAPPA was less than 0.05,showing the statistical difference.2.Clinical symptoms in the treatment group and control group after intervention was improved,while the treatment group was superior to the control group in improvement of main symptoms,subclinical hypothyroidism and placenta function.The total effective rate of TCM syndrome effect in the treatment group was higher than the control group.The pregnancy outcome in the treatment group was superior to the control group,showing the statistical difference.Conclusions:The method of tyishenjianpi exactly has an effect on early-stage threatened abortion combined with subclinical hypothyroidism.It not only increases the serum P and HCG level of patients with early-stage threatened abortion and enhance fetus protection success rate.Meanwhile,it can promote placenta trophocyte to secrete PAPPA,maintain stable development of fetus,and enhance pregnancy outcome.Meanwhile,it can significantly reduce TSH level,increase FT4 value and alleviate subclinical hypothyroidism.Moreover,it is safe and has the high acceptance for patients.Dynamic monitoring on serum PAPPA has the clinical application value on evaluating early-stage threatened abortion combined with subclinical hypothyroidism and prognosis.