Clinical Observation On Treating Epigastric Pain Syndrome Of Liver-stomach Disharmony With Chaihu Erjin Decoction

Objective:The purpose of this project is to assess the effect of the treatment by using tutor's self-made Chaihu Erjin decoction to treat the patients who were suffering from epigastric pain syndrome of liver-stomach disharmony.To assess the efficacy of Chaihu Erjin decoction so as to promote its clinical application.Methods:Sixty patients with EPS who meeting the criteria included in this study were randomly divided into two groups;In the treatment group,30 patients were treated with tutors' self-made Chaihu Erjin decoction.30 patients in control group were treated with lansoprazole.Two groups of patients were treated for 4 weeks.After treatment,the changes of the integral of TCM symptoms and the scores of TCM single symptom before and after treatment are observed and recorded,and the data are collected and analyzed in order to achieve the conclusion.Results:1.The total effective rate of TCM syndromes:The rate of total effective of the treatment group is 93.33%,but the control group is 73.33%.The overall efficacy of the treatment group is superior to the control group(P<0.05).2.The accumulation of total scores of TCM syndromes:The total score of TCM syndromes in both groups decreased significantly after treatment(P<0.01),but the efficacy of treatment group was better than that of the control group(P<0.01).3.The efficacy of main symptoms:The disappearance rate of main symptoms like pain in the epigastric region?distension in epigastric region and flanks in the treatment group respectively are 53.33%and 63.33%,it is better than the control group with 23.33%and 30.00%.Compared with the two groups,the difference is statistically significant,it shows that curative effect of treatment group is better than the control group in treating the main symptoms of distension and pain in the epigastric region.(P<0.05).4.The comparison of single symptom scores:.The single symptom scores in two groups are decreased significantly compared with those before treatment(P<0.01?P<0.05).The curative effect of the teatment group is better than the control group for the symptoms such as pain in the epigastric region?distension in epigastric region and flanks?sighing frequently ect(P<0.01),however,the control group is better than the treatment group in treating the stomach acid regurgitation and heartburn(P<0.01);Two groups have the same effect on irritability?postprandial fullness and unsmooth defecate(P>0.05).5.The comparison of HAMA/HAMD scores:After treatment,the scores of both groups are reduced significantly compared with before treatment(P<0.01),and the scores of the treatment group reduce significantly than the control group in both HAMA and HAMD(P<0.01).Conclusion:The results show that Chaihu Erjin decoction in the treatment of liver-stomach disharmony of EPS can improve the main symptoms such as fullness and pain in the epigastric region.It also has a good effect on other symptoms such as irritability?stomach acid regurgitation?heartburn?sighing frequently ect.At the same time,it can reduce the HAMA/HAMD scores,regulate anxiety and depression syndromes.Thus it can be seen that Chaihu Erjin decoction can obtain good clinical effect in the the patients who were suffering from epigastric pain syndrome of liver-stomach disharmony.