| Objective:By comparing with pantoprazole enteric-soluble capsule,the clinical efficacy of Oriental gastric medicine capsule in the treatment of functional dyspepsia epigastric pain syndrome（EPIGastric pain syndrome）was observed,in order to objectively evaluate the application advantage and value of Oriental gastric medicine capsule in the treatment of epigastric pain syndrome.Methods:Selection in November 2019 to June 2021 in the first hospital in wuhan city and into the standards of the 66 patients with EPS as research object,according to the method of random Numbers are divided into 2 groups,treatment group(33 cases,control group 33 cases,treatment group with Oriental stomach medicine capsule orally,the control group in panxi tora azole sodium enteric capsules orally,treatment period of treatment are 4 w,Followed up for 2 w.General clinical data such as gender,age distribution and disease course distribution of patients meeting the criteria were collected.Scores of major symptoms of epigastral pain and full hypochasm and secondary symptoms such as belching and pantothenic acid,VAS score of upper abdominal pain,anxiety and depression scale were used as observation indexes.After the treatment course,the curative effect of TCM syndromes,total score of TCM symptoms,single symptom score of TCM,VAS score of epigastric pain,disappearance rate of epigastric pain,SAS and SDS scale scores of the two groups were observed and compared,and the data were recorded.Results:1.Comparison of baseline data,there was no statistically significant difference in gender,age distribution and disease course distribution between the two groups before treatment（P >0.05）,with comparability.2.The total effective rate（clinical cure + apparent effect+ effective）of the treatment group was 93.70%,and that of the control group was 67.7%.Rank sum test showed that P=0.03 < 0.05,and the total effective rate of the treatment group was higher than that of the control group,the difference was statistically significant.3.Comparison of total SCORES of TCM symptoms: Statistical analysis showed that there was no significant difference in total scores of TCM symptoms between the treatment group and the control group before treatment（P > 0.05）.After treatment,the total scores of TCM symptoms in both the treatment group and the control group decreased significantly（P < 0.05）.The total score of TCM symptoms in the treatment group was lower than that in the control group,and the difference was statistically significant（P < 0.05）.4.There was no statistical significance in single symptom scores between the two groups before treatment（P > 0.05）,indicating comparability;After treatment,the scores of each single symptom in the two groups were decreased,with statistical significance（P < 0.05）.Between the two way through statistical analysis,the result showed that in the diagnosis of pain,swelling in at two side,belch,heartburn,pantothenic acid,good sigh improvements in symptoms integral,Oriental medicine capsule stomach curative effect more apparent,the difference was statistically significant（P < 0.05）,while in dry mouth mouth pain,irritability symptoms integral improved,P were greater than 0.05,there was no statistically significant difference.5.Comparison of VAS scores of upper abdominal pain between the two groups before treatment showed no statistical significance（P >0.05）,indicating comparability;After treatment,VAS scores in the second week and the fourth week in both groups were lower than those before treatment（P < 0.05）,and VAS scores in the second week and the fourth week in the treatment group were lower than those in the control group（P < 0.05）,which was statistically significant.6.The disappearance rate of upper abdominal pain was 78.1%（25/32）in the treatment group and 51.6%（16/31）in the control group after treatment,and the difference was statistically significant,P < 0.05 after statistical analysis.7.Comparing the SCORES of SAS and SDS,there was no statistically significant difference between the two groups before treatment（P > 0.05）,indicating comparability;After treatment,SAS and SDS scale scores of patients in the two groups were decreased,the differences were statistically significant（P < 0.05）,and the treatment group was better than the control group（P < 0.05）,that is,the efficacy of Dongfang Weiyao capsule was more obvious.8.Safety evaluation: No obvious abnormality was found in laboratory tests before and after treatment,and no adverse reactions occurred in patients in both groups.The safety was acceptable.Conclusion:For patients with upper abdominal pain syndrome and liver and stomach disharmony type,the digestive tract discomfort symptoms can be effectively alleviated by using Oriental stomach medicine capsule,and the drug can improve the quality of life of patients,which is a clinical choice. |
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