Detection Of P53 Gene Deletion In Uygur Esophageal Squamous Cell Carcinoma By Fluorescence In Situ Hybridization And Its Clinical Significance

Objective The study of TP53 gene deletion and p53 protein expression in Uygur's esophageal carcinoma,and correlation with prognosis.Methods Select 67 cases of Uygur esophageal squamous cell carcinoma treated by radical resection in our hospital.Using fluorescence in situ hybridization(FISH)and immuno-histo-chemistry(IHC)to detect TP53 gene deletion and p53 protein expression relationship with clinicopathological factors and postoperative survival rate Results In the highly differentiated group,the deletion rate of TP53 gene was 15%,in the Moderateand Poorly differentiation differentiated group was 40.43%,and the difference was statistically significant(P < 0.05).There was no significant difference in tumor invasion depth and lymph node metastasis(P > 0.05).There was no significant difference in the degree of p53 protein expression with the degree of tumor differentiation,tumor invasion depth and lymph node metastasis(P > 0.05).Conclusion The result shows that there is a certain correlation between TP53 gene deletion and the degree of esophageal carcinoma and tumor differentiation,but postoperative survival independent of TP53 gene deletion and p53 protein expression is not as the evaluation of the prognosis of patients with esophageal cancer of Uygur biomarkers need to increase sample size to further determine.