Clinical Significance Of NLR And PLR In Patients With Acute Exacerbation Of Asthma

Objective:To compare the changes of the ratio of neutrophil-lymphocyte ratio(NLR)and platelet-lymphocyte ratio(PLR)in the peripheral blood of patients with different severity of acute exacerbation of bronchial asthma.To explore its potential clinical significance for disease diagnosis and assessment.Methods:We retrospectively analyzed the clinical data of 192 patients with bronchial asthma in acute exacerbation admitted in our hospital in the past 6 years.According to the severity of the disease,asthma patients were divided into mild group,moderate group,severe group,and critical group.At the same time,190 healthy checkups were healthy control group.The general clinical data and statistical analysis of neutrophil-lymphocyte ratio(NLR)and platelet-lymphocyte ratio(PLR)were recorded in each group.Changes in the medium,presumably neutrophillymphocyte ratio(NLR)and platelet-to-lymphocyte ratio(PLR)may contribute to the diagnosis and assessment of bronchial asthma severity and potential mechanisms.Results:1.There was no significant difference in gender and age between asthma exacerbation group and healthy control group(P>0.05).There was no significant difference in the gender,age,use of drug control,and smoking history among asthma exacerbation groups(P>0.05).There was a statistically significant difference in the age of first onset and family history(P<0.05).The WBC,neutrophil count,NLR and PLR in patients with acute asthma were higher than those in the control group.There was a significant difference between the two groups(P<0.001).The number of lymphocytes in patients with acute asthma was lower than that in the control group.There was a significant difference between the two groups(P<0.001).There was no significant difference in the number of platelets between patients withacute asthma and the control group(P>0.05).2.The WBC of critical group patients with acute exacerbation of asthma was higher than that of healthy group,mild group,moderate group,and severe group,and there was a significant difference in different degree groups(P<0.001).The neutrophils of critical group patients with acute attacks of asthma was higher than that in the healthy group,the mild group,the moderate group and the severe group,and there was a significant difference in different degree groups(P<0.001).The lymphocytes of critical group patients in acute attacks of asthma was lower than that in severe group,moderate group,mild group,and health.There was a significant difference in different degree groups(P<0.001).The PLT of critical group patients in acute attacks of asthma was lower than that in mild group,moderate group,severe group and healthy group.There was no significant difference between different degree groups(P>0.05).The NLR of critical group patients in acute attacks of asthma was higher than that in the healthy group,the mild group,the moderate group and the severe group.There is a significant difference between different degree groups(P<0.001).ThePLR of critical group patients in acute attacks of asthma was higher than that in the healthy group,the mild group,the moderate group and the severe group.There is a significant difference between different degree groups(P<0.001).3.(1)The AUC of WBC,neutrophil count,lymphocyte count,NLR and PLR in the acute attack patients were 0.682,0.726,0.694,0.786,and 0.694(P all < 0.001);The best cut-off value of NLR in the diagnosis of acute asthmatic patients was 2.23,the sensitivity was 67.7%,and the specificity was 82.1%.The best cut-off value of PLR in the diagnosis of acute asthmatic patients was 135.98,and the sensitivity was51%,and the specificity was 82.1%.(2)The AUC of WBC,neutrophil count,lymphocyte count,NLR,and PLR for critically ill patients with acute asthma were 0.747,0.767,0.684,0.769,and 0.649(P all <0.001);The best cut-off value of NLR in the diagnosis of critically ill patients with acute asthma attack was 4.461,the sensitivity was 70%,and the specificity was 77.6%.The best cut-off value of PLR in the diagnosis of critically ill patients with acute asthma attack was 162.5,the sensitivity was 57.5%,and the specificitywas 71.1%.Conclusion:NLR and PLR can be used as an indicator for severity assessment of acute asthma attack.It can provide help for the standardized treatment of asthma and monitoring of the condition of the asthma.