Application Value Of Neutrophil-Lymphocyte Ratio And Platelet-Lymphocyte Ratio In Children With Asthma

Research purposesAnalyzed and compared the neutrophil-lymphocyte ratio(NLR)and platelet-lymph ocyte ratio(PLR)in children with bronchial asthma with different severity of disease,to investigate the diagnostic value and clinical significance of the changes in child ren with asthma.Research methodsAccording to the diagnostic criteria for the prevention and treatment of childhood bronchial asthma developed by the Chinese Medical Association in 2016 [1],120 cases of asthmatic children admitted to our hospital from December 2016 to June 2018 were collected as case groups,according to the severity of the acute illness.Asthmatic reconstitution and non-risk reorganization of asthma(including mild,moderate,and severe patients).Thirty healthy children with no statistical differences in age and gender were selected as healthy controls.Record the general clinical data such as age,gender,and illness of eligible children and conduct retrospective analysis to summarize the clinical characteristics and comorbidities of children with asthma,and collect the blood routine indicators of the children through the inpatient medical record test system.The granulocyte-lymphocyte ratio(N/L)and platelet-lymphocyte ratio(P/L)were statistically analyzed.The receiver operating curve(ROC curve)was used to evaluate the absolute value of neutrophils and the absolute value of lymphocytes.The diagnostic value of PLR and NLR in different severity of asthma exacerbations.Research results1.There was no significant difference in gender and age between the asthmatic acute attack group and the healthy control group(P>0.05).In the children with different degreesof asthma exacerbation,there was no significant difference in gender and age(P>0.05),and the family history between the children with different degrees was statistically significant.2.The white blood cell count,neutrophil count,platelet count,NLR and PLR of children with acute asthma attack were higher than the control group,and the difference was significant.The LYM of children with acute asthma was lower than that of the control group.However,there was a significant difference between the two groups.3.The white blood cell count,neutrophil count,platelet count,NLR and PLR of children with acute asthma attack were higher than those of healthy group,mild group,moderate group and severe group.There were significant differences in different degrees.LYM in children with acute asthma exacerbation was lower and there were significant differences in different degrees and groups.The acute resuscitation of asthma was higher in NLR and PLR than in healthy,mild,moderate,and severe groups.There were significant differences in different degrees.4.The area under the curve of WBC,NEU,LYM,NLR,and PLR for the diagnosis of acute asthma attack were 0.739,0.737,0.661,0.822,and 0.873,respectively(P < 0.001).Among them,NLR is the best diagnosis for patients with acute asthma attack.The cut-off value was 4.458,the sensitivity was 75.3%,and the specificity was 77.8%.The optimal cut-off value of PLR for patients with acute asthma attack was 172.342,the sensitivity was66.0%,and the specificity was 72.1%.The AUC of patients with critical asthma attack by WBC,NEU,LYM,NLR,and PLR were 0.676,0.742,0.669,0.783,and 0.875,respectively(P < 0.001).The optimal threshold for NLR diagnosis of critically ill patients with acute asthma The value was 4.512,the sensitivity was 66.50%,and the specificity was71.7%.The optimal cut-off value of PLR for critically ill patients with acute asthma was171.29,the sensitivity was 76.9%,and the specificity was 78.4%.Analysis conclusions1.Peripheral blood WBC,NEU,PLT,NLR,and PLR were all elevated in children with bronchial asthma,and LYM decreased.2.NLR and PLR can be used as reference indicators for assessing the severity of asthma exacerbation,and have certain clinical guiding significance for the monitoring of childhood bronchial asthma.