Relationship Between HPV Infection Of Cervical And Fallopian Tube And Tubal Pregnancy

Objective: To study the correlation between human papillomavirus(HPV)infection in the cervix and fallopian tube and tubal pregnancy,and to provide a theoretical basis for its diagnosis and treatment.Methods: Tubal pregnancy in 96 patients(observation group)of cervical mucosal HPV samples and the same patient with tubal mucosa HPV samples were selected in the Chengde City Central Hospital gynecology from October2015 to September 2017.We quantified the above samples by liquid-based thin-layer smear fluorescence PCR(realtime fluore-scence quantitative PCR,RTFQ PCR).We selected my hospital 40 patients(control group)of uterine fibroids,uterine adenomyosis,ovarian benign cyst torsion to select cervical and tubal mucosal HPV detection by the same way.The aim was to compare the differences in HPV infection rates between the two groups of cervical and fallopian tubes,and compare HPV subtype distribution in cervical samples and fallopian tubes,and analysis the correlation between the number of tubal pregnancy and HPV infection rate.Result:1 Comparison of HPV Infection Rate between Cervical Samples and Fallopian Tube in two SubjectsThere were 33 cases(34.3%)of HPV positive in the cervical samples of the observation group and 5 cases(12.5%)of HPV positive in the cervical samples of the control group,P =0.011;The positive HPV in the observation group was 29 cases(30.2%),and the positive HPV in the control group was 3cases(7.50%),P =0.04;The positive rate of HPV and the positive rate of HPV in ovariectomized samples were higher than those in the control group,and the difference was statistically significant(P <0.05)Table 2.2 Comparison of distribution of HPV subtypes in cervix samples fromtwo groupsThe detected high-risk HPV16 was 21 cases(21.9%)in the observation group,was 2 cases(5.00%)in the control group of cervix samples respectively.The difference between the two was statistically significant(P<0.05).There were 5 cases(5.21%)in the observation group and 2 cases(5.00%)in the control groupin the high-risk group of HPV18.There was no significant difference between the two groups(P>0.05).There was no statistical significance in the other subtypes of high-risk HPV in the observation group and the control group.There were 3 cases(3.13%)of low-risk HPV of the observation group and 1 case(2.50%)in the control group in the cervical samples,the difference was not statistically significant(P> 0.05)Table 3.3 Comparison of distribution of HPV subtypes in tubal samples of two groupsThere were 3 cases(3.13%)in the observation group and 0 cases(0%)in the control group of high-risk HPV18,the difference was not statistically significant.High-risk HPV16 detected cases in the observation group and control group were 4 cases(4.17%)and 1 case(2.50%)respectively.There was not statistically significant.There were 2 cases(2.08%)of low-risk HPV detection cases in the observation group and 1 case(2.50%)of the low-risk type of HPV in the control group.The difference was not statistically significant(P>0.05).In the observation group,19 cases(19.79%)of other high-risk HPV cases were significantly higher than those of other high-risk HPV cases in the control group,the difference was statistically significant(P<0.05)Table 4.4 Analysis of the correlation between the number of tubal pregnancy and HPV infection rate of tubal in observation groupAs shown in Table 5,2 cases(3.08%)and 0 cases(0%)were found in the tubal samples of the low-risk type of HPV with fallopian tube pregnancy 1and 2 time groups respectively.The difference was not statistically significant(P>0.05).There were 13 cases(20.0%)and 14 cases(45.16%)of high-riskHPV in the 1 and 2 time groups respectively of tubal pregnancy.The difference was statistically significant(P <0.05).5 Analysis of the correlation between the number of tubal pregnancy and cervix HPV infection rate in observation groupAs shown in Table 6,3 cases(4.61%)and 0 cases(0%)were found in the cervix samples of the low-risk type of HPV with fallopian tube pregnancy1 and 2 time groups respectively.The difference was not statistically significant(P>0.05).There were 14 cases(21.54%)and 16 cases(51.61%)of high-risk HPV in the 1 and 2 time groups respectively of tubal pregnancy.The difference was statistically significant(P<0.05).Conclusions: Cervical and fallopian tube HPV infection and tubal pregnancy were closely linked;high-risk HPV infection on the occurrence of tubal pregnancy was important;tubal pregnancy and high-risk type of HPV infection was positively correlated.