The Changes Of Bone Mineral Density And Their Correlation With Target Organ Damage In Elderly Patients With Metabolic Syndrome

Objective To observe whether there is a change in bone mineral density in elderly patients with metabolic syndrome and to understand the relationship between each component of metabolic syndrome and bone mineral density and to explore the correlation between bone mineral density and target organ damage in heart,brain and kidney with metabolic syndrome.Methods In our study,37 elderly healthy controls and 66 elderly patients with metabolic syndrome were selected from January 2017,to December 2017 in the General Hospital of Ningxia Medical University.According to the presence or absence of hypertension,the metabolic syndrome patients were divided into HMS group and MS group.Height,weight,abdominal circumference,blood pressure were measured.Fasting blood glucose(FPG),triglyceride(TG),low density lipoprotein cholesterol(LDL-C),high density lipoprotein cholesterol(HDL-C),uric acid,serum creatinine(Scr),Intima-media Thickness(IMT),Left Ventricular Diastolic diameter(LVDd),Interventricular Septal Thickness(IVST),Left Ventricular Posterior Wall Thickness(LVPWT),and bone mineral density(T-score)of L1-L4 lumbar vertebrae by dual energy X-ray absorptiometry were measured and the glomerular filtration rate(eGFR)and left ventricular mass index(LVMI)were calculated.Then,we did a set of data statistical analysis by SPSS17.0 software.Results(1)There were significant differences in BMI,FPG,TG,TC,LDL-C,HDL-C,uric acid systolic pressure and diastolic pressure among MS group,HMS group and control group(P<0.05).Compared with the control group,the abdominal circumference,body weight,BMI,FPG,TG,TC,LDL-C and uric acid of MS group were increased significantly and HDL-C were decreased significantly in MS group.the difference was statistically significant(P<0.05),Systolic blood pressure,abdominal circumference,body weight,BMI,FPG,TG,TC LDL-C and uric acid were increased significantly and HDL-C were decreased significantly(P<0.05)in HMS group.Compared with MS group,systolic and diastolic blood pressure were increased significantly(P<0.05).(2)There was significant difference in bone mineral density among MS group,HMS group and control group(P<0.05).Compared with the control group,the bone mineral density in HMS and MS group were decreased significantly,with statistical significance(P <0.05).However,there was no significant difference in bone mineral density between MS group and HMS group(P>0.05).(3)TG,TC,FPG,Hypertension and uric acid were the influencing factors of bone mineral density in elderly metabolic syndrome.Pearson correlation showed that the T value of bone mineral density was positively correlated with uric acid(r=0.270),and negatively correlated with abdominal circumference,SBP,and age(r=-0.294,-0.236,-0.247respectively)(P<0.05).Binary logistic regression analysis showed that age and diabete were the risk factors(P <0.05).and uric acid was the protective factor of bone mineral density(P <0.05).(4)Compared with the control group,IMT and LVMI were both increased,however eGFR was decreased in MS and HMS group((P <0.05).Pearson correlation showed that the T value of bone mineral density was negatively correlated with LVMI and LVDd(r =-0.125,0.198 respectively).Conclusion(1)The bone mineral density of elderly patients with metabolic syndrome was significantly lower;(2)The abdominal circumference,triglyceride,cholesterol,hypertension,blood glucose and uric acid are the influencing factors of bone mineral density.Diabetes and age are independent risk factors of bone mineral density,uric acid is a protection factor for bone mineral density;(3)patients with metabolic syndrome have target organ damage.However,there is might a correlation between bone mineral density and LVMI with metabolic syndrome.