Evaluation Of Liver Function Damage By DWI Combined With DCE-MRI In Chronic Hepatitis B

Objective:To evaluate the value of DWI combined with the time signal intensity curve of DCE-MRI in the evaluation of liver function damage in chronic hepatitis B.Methods:Using Philips 1.5 T DWI MRI and dynamic contrast-enhanced scan in 37cases of chronic hepatitis B patients and normal adult abdomen(liver)in 26 cases,measured the ADC value of liver when the b value is 600 s/mm~2 and semi quantitative parameters of TIC and then compare with normal adults,The ADC value of the patients with chronic hepatitis B and the related indexes of clinical laboratory observation were analyzed,and the hepatic fibrosis was evaluated.Results:(1)The ADC value of the chronic hepatitis B group was significantly lower than that of the control group with the same b value,and there was significant difference between the two groups,and the difference was statistically significant(P<0.05).(2)The DCE-MRI parameters of the chronic hepatitis B group and the healthy control group(ME,MRE,TTP,WIR)were different,and the difference was statistically significant(P<0.05).(3)All the semi quantitative parameters of DCE-MRI in HBV group had a good correlation with the ADC value of liver parenchyma(correlation coefficients were 0.603,0.399,-0.602,0.333).ME,MRE and WIR were positively correlated with ADC value,and TTP was negatively correlated with ADC value.(4)When b=600s/mm~2,the ADC value of chronic hepatitis B liver parenchyma correlated well with clinical biochemistry related indicators ALT,AST and TBil(correlation coefficient was-0.369,-0.379,-0.414),and negatively correlated with PT.Conclusion:(1)Under the same b value,the ADC values of CHB group were significantly lower than those of the control group.The DCE-MRI parameters(ME,MRE,TTP,WIR)were significantly different from those of the normal population.DWI plus DCE-MRI could provide some help for the clinical diagnosis of the liver damage induced by CHB.(2)When b=600s/mm2,chronic hepatitis B liver parenchyma ADC value combined with clinical serological observation indicators ALT,AST,TBil can evaluate liver damage to a certain extent.