Study On The Evaluation Method For Teaching Effect With Autism Spectrum Disorder

Autism is a representative of extensive developmental disorder, which is a long-term developmental disorder start in infant period caused by brain dysfunction. At this stage the main treatment method is psychological intervention based on psychologic principle and method to improve psychology, behavior and social function of autism children. In order to evaluate the effect of interventions interviews are usually carries out for children's parents or teachers as well as the use of the autism treatment evaluation scale (Autism Treatment Evaluation Checklist, ATEC). But the use of impact assessment scale would be affected by the subjective attitude of the parents, unable to get accurate results. This paper focus on the development of the assessment for autism intervention effect by noninvasive biochemical detection. 1. The optimization of sampling and the determination of noninvasive biochemical samples of autism childrenThe current method for saliva collection was making the subjects directly spit saliva in a appropriate container till enough or swabbing it into rods and filter paper strip. But for children especially autism children these methods are difficult to operate. To solve this problem and considering the characteristics of autistic children, two kind of saliva sampling scheme were designed, one was base on filter paper the other was double tube type sampler. And a rapid detection of salivary amylase was optimized.. 2. The measurement of salivary amylase in autism children for evaluating teaching effectAfter receiving the teaching both normal children and autism children have significant changes in salivary amylase level. Before the class, the baseline level of salivary amylase had a very significant difference between autism group and the normal group, but the variations of salivary amylase levels were no significant between the two groups. Moreover, an obvious rhythm was observed in salivary amylase daytime. 3. Determinations of multiple markers for the application in evaluating teaching effects in autism childrenAfter a period of teaching intervention for autism children, several biochemical markers other than saliva amylase were determined. It was found that not only the changes of the cognitive behaviors were observed, but the levels of biochemical markers were also changed markedly, and the trend is conducive to healthy development.