Clinical Observation Of Traditional Chinese Medicine Combined With Targeted Drug Gefitinib In The Treatment Of Advanced Non-small Cell Lung Cancer

Lung cancer is the malignant tumor with the highest incidence and mortality of tumor.And because of the hidden, clinical symptoms and treatment for most patients with late,current therapy for advanced non-small cell lung cancer with platinum containing two drugs combined with chemotherapy for standard scheme. However, many prospective phase III clinical studies have confirmed that,regardless of the median surival time,response rate,efficiency,1year surival time has arrived the bottleneck,and advanced patients tend to have poorer health status, intolerance to the second or even three line chemotherapy,therefore,in recent years,with its efficient,targeted drug low toxic fast into the people's vision.Gefitinb is a relatively specific anti-tumor drug targeting,through selecive inhibition of the epidermal growth factor receptor tyrosine kinase (EGFR-TK) signaling pathways play a role,the failure of chemotherapy in patients with NSCLC have significant anti-cancer effect.TCM believes that lung cancer is due to weakness of the body,internal organs disorders,or outside intrusion lung,cold and heat too that qi stagnation,blood stasis and toxin within the knot,but in lung product.Chinese medicine treatment of purpose is the general mobilization of the body upright,upright to support the attack of the evil influences.Chinese medicine treatment of lung cancer has the advantage of stable tumor lesions,prevent tumor recurrence or metastasis,improve clinical symptoms,reduce the toxicity of chemotherapy,improve the quality of life,extend the period of survival aspects. At present can not be radical resection in the treatment of advanced non small cell lung cancer is difficult that how to improve the quality of life of patients,patients with prolonged survival, palliation of patients with adverse reaction,improve the clinical symptoms of the patients with.The clinical observation is prospective clinical research method of the observed, traditional Chinese medicine dialectical combination treatment for the treatment of advanced,the auspicious non-small cell lung cancer patients for clinical curative effect.Objective:To observe the traditional Chinese medicine dialectical treatment with Gefitinib for the treatment of advanced non-small cell lung cancer patients with objective tumour response, clinical benefit rate, Karnofsky scores, the main clinical symptom, disease progression free surival,6months and1year surival rates and non sunitinib, security and other aspects of the impact.Methods:According to certain diagnosis,into,exclusion standard to the Guanganmen hospital clinic and ward in2010August to2012March were collected during99cases, all cases were oral, Gefitinib250mg Po Qd, traditional Chinese medicine therapy in advanced non-small cell lung cancer traditional Chinese medicine typing respectively to the syndrome of medication and some anticancer Chinese herbal medicine,15days for thel course, even serving after6courses of treatment, using their own control, evaluation before and after treatment with tumour objective efficiency, Karnofsky scores to change the situation, the main clinical symptoms, progression free survival and Kyrgyzstan non Gefitinib safety.Results:This study without shedding case,all patients had complete clinical observation.Objective tumour response for40.4%,with a selecive population IPASS test results similar to those of43%,higher than that of IDEAL1test observation of18.4%; clinical benefit rate was78.8%,but as a result of test conditions,methods and scheme is different,so do not have statistical significance. In the subgroup analysis,younger age,adenocarcinoma,gene mutation posiive,not smoking or a small amount of smoking patients with efficiency and clinical benefit rate was higher than that of older, squamous cell carcinoma and other types,gene mutation negative,often in smokers.In gender,clinical staging, family history and different TCM Syndromes of type no obvious difference between.The quality of life of patients and TCM symptoms integral in improved significantly after treatment, P<0.05, with statistical difference. Cough, expectoration, hemoptysis in,shortness of breath, fatigue and other symptoms improved by statistical analysis has obvious difference; before and after the treatment in the patients with weight had no significant difference,P>0.05,not statistically significant; in all patients, the median progression-free survival was6months,6months of survival rate is94.9%,1year surival rate was69.7%; In adverse reaction rate, acne skin rash rate of68.7%of the sample, peeling20.2%, itchy skin is44.8%, diarrhea, nausea and vomiting for62.1%to4.0%, and3.0%of transaminases associated, bleeding from the nose for7.1%, close the occurrence of qualitaive pneumonia.Conclusion:Traditional Chinese medicine combined with Gefitinb in treatment of advanced non small cell lung cancer have improved clinical benefit rate effect; improvement in patients with certain clinical symptom; improve the quality of life of patients.