Clinical Study Of Fuzheng Oral Liquid Combined With Chemotherapy In The Treatment Of Stage IIIB-IV Non-small Cell Lung Cancer With Qi And Blood Deficiency

Purpose:This study by observing clinical data of clinical efficacy,quality of life,immune function,TCM syndrome score,adverse reaction and other clinical data of Patients with late stage without surgery indications of qi and blood deficiency type?B-? NSCLC patients who were treated with Fuzheng oral liquid combined with chemotherapy,to determine the clinical efficacy of Fuzheng oral liquid adjuvant chemotherapy in the treatment of late qi and blood deficiency NSCLC patients.At the same time,based on the mature MRP serum detection technology in our department,we try to explore the possibility of reversing tumor multi drug resistance by observing the concentration of multi drug resistance protein(MRP)in serum.Expect to find a chemotherapy sensitizer and drug resistance reversal agent of late non-small cell lung cancer.Methods:This study Used the open randomized controlled trial methods,total of 44 qualifiedpatients were randomly divided into two group,2 2 eases in which the ob servati ongroup,22 patients in control group,considering the abscission factors.Thetreatment group adopts conventional chemotherapy combined with Fuzheng oral liquid to oral;The control group only recei vedcon venti onal chemotherapy in the treatment.Clinical efficacy was assessed by ob serving efficacy indicators and safety indicators.The efficacy indicators included recent curative effect,quality of life,immune function,TCM syndrome score and serum MRP content.Analyzed by SPSS19.0 statistics software.Results:(1)Thi s study included 44 patients,treatment for cases of loss factor in the process,the actual into the statistical analysis of the number of cases for 40 cases,treatment group 2 0 cases and control group 20 cases.By statistically analyzing the data before treatment,we found that the basic conditions of the two groups on gender,pathological type,chemotherapy,KPS,age,etc,have no obvious difference(P>0.05).It means the two groups were comparable.(2)Recent efficacy:The effective rate and stability of the treatment group were slightly higher than those of the control group,but the difference was not significant,indicating that the treatment group had no significant effect on the tumor size.(3)The quality of life:Comparison of the Efficient of KPS score changes between two groups after treatment has significant difference(P<0.05);The quality of life of the treatment group was higher than that of the control group.(4)Immune function:Through the comparison of CD3+,CD4 +,CD8 +,CD4 +/CD8 +,between the two groups before and after treatment,we found that the humoral immunity in observation group is better than that of the control group after the treatment(P<0.05).(5)TCM symptom improvement:After the treatment there was significant differences between the two groups in the overall symptomimprovement rate(P<0.05);The improvements of observation group were significantlyhigher than the control group.(6)MRP quantitative:After the treatment the average MRP level in the treatment group was lower than that in the control group(P<0.05),indicating that the treatment group could significantly inhibit the expression of MRP in the serum.(7)Toxicities:There was no significant difference in the bone marrow suppression,liver function grading and gastrointestinal reaction between the treatment group and the control group during the first period of chemotherapy(P>0.05).During the second cycle of chemotherapy,There was no significant difference in the liver function between the treatment group and the control group(P>0.05),while there was significant difference between the treatment group and the control group(P<0.05).The results showed that with the prolongation of chemotherapy time,the treatment group was better than the control group in reducing the effect of chemotherapy on bone marrow suppression and alleviating the gastrointestinal reaction.Conclusions:Fuzheng oral liquid combined with chemotherapy in the treatment of qi and blood deficiency type non-small cell lung cancer patients has an effective way to improve TCM symptoms,protect immune function,improve quality of life,reduce bone marrow suppression,gastrointestinal reactions and other toxic side effects and so on,thereby enhancing the efficacy of chemotherapy?But it is not prompted to significantly reduce the possibility of tumor.MRP is a multidrug resistance mechanism.This topic suggests that Fuzheng Oral Liquid can significantly inhibit the expression of MRP in serum.It can be presumed that Fuzheng Oral Liquid can reverse the MRP-mediated multi drug resistance in non-small cell lung cancer,thereby improving the overall efficiency of chemotherapy.